Neuromagnetic SII responses do not fully reflect pain scale

Wei Ta Chen, Rey Yue Yuan, Yang Hsin Shih, Tzu Chen Yeh, Daisy L. Hung, Zin An Wu, Low Tone Ho, Yung Yang Lin

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

To elucidate the role of somatosensory cortices in coding pain magnitude, we recorded the neuromagnetic responses of ten subjects to mild, moderate, and severe pain stimulation by delivering thulium-laser pulses on the dorsum of the left hand. The stimulus intensities for producing different pain levels were determined individually, and the mean values across subjects were 255, 365, and 490 mJ for mild, moderate, and severe pain, respectively. We obtained 40 responses for each intensity condition, and analyzed the averaged cortical signals by multi-dipole modeling. All subjects showed consistent activation over the bilateral secondary somatosensory (SII) cortices for each intensity level, peaking around 150-230 ms, with 15-ms earlier on the contralateral hemisphere. The SII dipole strength was significantly larger for the moderate than for the mild pain stimulation, but lacked further increase as the pain magnitude elevated to the severe level. In contrast, the primary somatosensory cortical response was detected in only half of our subjects, and thus it seemed difficult to evaluate its role in pain intensity coding. Our results suggest that activation strength in human SII cortices reflects the magnitude of peripheral noxious inputs only up to the moderate level, and some other cerebral correlates may get involved in sensing a further increment of pain magnitude.

原文英語
頁(從 - 到)670-676
頁數7
期刊NeuroImage
31
發行號2
DOIs
出版狀態已發佈 - 六月 2006

    指紋

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

引用此

Chen, W. T., Yuan, R. Y., Shih, Y. H., Yeh, T. C., Hung, D. L., Wu, Z. A., Ho, L. T., & Lin, Y. Y. (2006). Neuromagnetic SII responses do not fully reflect pain scale. NeuroImage, 31(2), 670-676. https://doi.org/10.1016/j.neuroimage.2005.12.015