Neurogenic diabetes insipidus in children with hypoxic encephalopathy: Six new cases and a review of the literature

Yann Jinn Lee, Fu Yuan Huang, Ein Yiao Shen, Hsin An Kao, Man Yau Ho, Shyh Dar Shyur, Nan Chang Chiu

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

Hypoxic encephalopathy is rarely mentioned as a cause of neurogenic diabetes insipidus (DI) in children. We here report six cases of DI which occurred after severe hypoxic/ischaemic brain damage and include a review of the literature on 28 paediatric cases of neurogenic DI due solely to severe hypoxia/ischaemia. Airway obstruction, haemorrhagic shock and sudden infant death syndrome are the three major causes of hypoxia/ischaemia. The ages (25/28) ranged from 0.03 to 18 years (mean 7.27 years, median 5 years). The intervals between the hypoxic insult and the onset of DI (23/ 28) ranged from 0.08 days (2 h) to 13 days (mean 4.07 days, median 3.5 days). Linear regression analysis revealed no significant correlation between the age and the interval. Nine teen cases (82.6%) developed DI within 6 days after the hypoxic/ischaemic insult. Only two neonates survived with developmental delay. The remaining 26 cases died. Conclusion. Neurogenic DI can be caused by hypoxia/ischaemia and is an omnious sign of severe brain damage in children with hypoxic encephalopathy. It is important to recognize this potential sequel by regularly monitoring intake and output, plasma sodium level, and urine specific gravity.

原文英語
頁(從 - 到)245-248
頁數4
期刊European Journal of Pediatrics
155
發行號3
DOIs
出版狀態已發佈 - 二月 13 1996
對外發佈Yes

指紋

Neurogenic Diabetes Insipidus
Brain Hypoxia
Diabetes Insipidus
Ischemia
Specific Gravity
Sudden Infant Death
Hemorrhagic Shock
Airway Obstruction
Linear Models
Sodium
Regression Analysis
Urine
Newborn Infant
Pediatrics
Brain
Hypoxia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

引用此文

Neurogenic diabetes insipidus in children with hypoxic encephalopathy : Six new cases and a review of the literature. / Lee, Yann Jinn; Huang, Fu Yuan; Shen, Ein Yiao; Kao, Hsin An; Ho, Man Yau; Shyur, Shyh Dar; Chiu, Nan Chang.

於: European Journal of Pediatrics, 卷 155, 編號 3, 13.02.1996, p. 245-248.

研究成果: 雜誌貢獻文章

Lee, Yann Jinn ; Huang, Fu Yuan ; Shen, Ein Yiao ; Kao, Hsin An ; Ho, Man Yau ; Shyur, Shyh Dar ; Chiu, Nan Chang. / Neurogenic diabetes insipidus in children with hypoxic encephalopathy : Six new cases and a review of the literature. 於: European Journal of Pediatrics. 1996 ; 卷 155, 編號 3. 頁 245-248.
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