Neural networks during delay discounting as trans-disease marker: A meta-analytical review

Zhiyi Chen, Benjamin Becker, Pengmin Qin, Wei Lei, Jing Chen, Peiwei Liu, Tian Lin, Chenyan Zhang, Rong Zhang, Mengmeng Wang, Ting Xu, Yaqi Yang, Pan Feng, Tingyong Feng

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1 引文 斯高帕斯(Scopus)


Delay discounting reflects a devaluation of delayed long-term benefits but pursuing immediate rewards. Higher discounting rates (h-DR) are found ubiquitous in many diseases and unhealthy conditions, particularly in addiction disorder (AD), attention-deficit/hyperactivity disorder (ADHD), and obesity. Thus, h-DR was considered to be a common benchmark across many diseases facilitating to understand one disease to relevant others, which was called trans-disease process. However, the common and specific neural biomarkers associated with this process has not yet been studied well. We performed a voxel-wise task-related neuroimaging meta-analysis to clarify the neural pattern of trans-disease process across AD, ADHD and obesity. We recruited 19 eligible papers, including 9 AD papers (154 patients), 6 ADHD papers (106 patients) and 4 obesity studies (94 patients). Neuroimaging meta-analysis demonstrated the presence of neural biomarkers of trans-disease process: these patients showed inadequate brain response in caudate, ventromedial and dorsolateral prefrontal cortex (dlPFC) than do of healthy controls (HCs). Disease-specific neural patterns were also found, with prominent hypoactivation in parahippocampal-striatum network for AD, hyperactivation in dopamine-projection striatum network for ADHD and decreased activity in dorsal anterior cingulate cortex and dlPFC for obesity. This study provided robust evidence to reveal the neural substrates of trans-disease process, as well further promoted the triple brain network model in favor of the theoretical developments of these neuropsychiatric disorders.

頁(從 - 到)62-70
期刊Journal of Psychiatric Research
出版狀態已發佈 - 7月 2021

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 生物精神病學


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