Neural mechanisms of impaired micturition reflex in rats with acute partial bladder outlet obstruction

C. T. Chien, H. J. Yu, T. B. Lin, C. F. Chen

研究成果: 雜誌貢獻文章

48 引文 (Scopus)

摘要

To determine the contribution of neural elements to micturition, we evaluated, in intact rats, the cystometrogram, pelvic afferent nervous activity, pelvic efferent nervous activity and external urethral sphincter-electromyogram activity in the normal and acute partial bladder outlet obstruction states. In the normal state, in response to saline filling, mechanoreceptor-dependent pelvic afferent nervous activity gradually activated and finally triggered a voiding reflex, including four phases of detrusor contractions. Phase 1 was characterized by an initial rising intravesical pressure, Phase 2 was characterized by a series of high-frequency oscillations in intravesical pressure, Phase 3 contraction was characterized by a rebound intravesical pressure and Phase 4 contraction was characterized by a rapid fall in intravesical pressure. In the acute partial bladder outlet obstruction state, Phase 1 contraction rose and high-frequency oscillations fell in Phase 2. This voiding dysfunction is ascribed to the bursting extraurethral sphincter activity being converted to tonic extraurethral sphincter activity.In summary, the suppressed high-frequency oscillations in Phase 2 of the detrusor muscle contraction could be detrimental to efficient voidings in the acute partial bladder outlet obstructed rat. Copyright (C) 1999 IBRO.

原文英語
頁(從 - 到)221-230
頁數10
期刊Neuroscience
96
發行號1
DOIs
出版狀態已發佈 - 一月 2000
對外發佈Yes

指紋

Urinary Bladder Neck Obstruction
Urination
Reflex
Pressure
Mechanoreceptors
Electromyography
Urethra
Muscle Contraction
Urinary Bladder

ASJC Scopus subject areas

  • Neuroscience(all)

引用此文

Neural mechanisms of impaired micturition reflex in rats with acute partial bladder outlet obstruction. / Chien, C. T.; Yu, H. J.; Lin, T. B.; Chen, C. F.

於: Neuroscience, 卷 96, 編號 1, 01.2000, p. 221-230.

研究成果: 雜誌貢獻文章

Chien, C. T. ; Yu, H. J. ; Lin, T. B. ; Chen, C. F. / Neural mechanisms of impaired micturition reflex in rats with acute partial bladder outlet obstruction. 於: Neuroscience. 2000 ; 卷 96, 編號 1. 頁 221-230.
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