Neural control of goblet cell secretion in guinea pig airways

K. Tokuyama, H. P. Kuo, J. A.L. Rohde, P. J. Barnes, D. F. Rogers

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99 引文 斯高帕斯(Scopus)

摘要

We studied the neural control of goblet cell secretion in the lower airways of anesthetized guinea pigs using a semiquantitative morphometric technique. The magnitude of discharge of intracellular mucus was determined in histological sections of the trachea and main bronchi stained for mucus glycoproteins. Bilateral electrical stimulation of the cervical vagus nerves induced goblet cell secretion. The magnitude of the effect was dependent on the frequency, voltage, and pulse width of the stimulus, and the duration of stimulation. At 10 Hz, 5 V, and 5 ms for 3 min, there was a 62% decrease in the amount of intracellular mucus below that with sham stimulation. The secretion was blocked either by atropine or by pretreatment with capsaicin but was not significantly inhibited by idazoxan, an α-adrenoceptor antagonist. The magnitude of goblet cell discharge in animals pretreated with propranolol was intermediate between that in controls and that with nerve stimultion, although not significant to either. These results demonstrate that goblet cell secretion is under neural control in guinea pig airways and suggest that cholinergic, nonadrenergic-noncholinergic, and possibly adrenergic neural pathways, may contribute to the secretion.
原文英語
期刊American Journal of Physiology - Lung Cellular and Molecular Physiology
259
發行號2 3-1
出版狀態已發佈 - 一月 1 1990
對外發佈

ASJC Scopus subject areas

  • 生理學
  • 肺和呼吸系統醫學
  • 生理學(醫學)
  • 細胞生物學

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