Nephrotic syndrome associated with a clonal T-cell leukemia of large granular lymphocytes with cytotoxic function

S. V. Orman, G. P. Schechter, J. Whang-Peng, J. Guccion, C. Chan, R. S. Schulof, R. J. Shalhoub

研究成果: 雜誌貢獻文章

摘要

A 51-year-old man presented with a T-cell leukemia of large granular lymphocytes and rapidly developed a nephrotic syndrome due to presumptive minimal-change glomerulopathy. The E-rosette+, Ia+ cells demonstrated cytotoxic activity similar to that of natural killer lymphocytes but lacked other T-subset markers, except that one third of them bore Fc(IgG) receptors. Cytogenetic analysis revealed loss of chromosome 10 and the translocation (1;10)(p11;q11) in all metaphases. Regression of the leukemia after chemotherapy was accompanied by a dramatic resolution of the nephrotic syndrome, suggesting that the activated granular lymphocytes induced the renal lesion. The close association of a clonal T-lymphoproliferative disorder with minimal-change nephrotic syndrome lends further support to current views implicating activated T cells or their products in the pathogenesis of this glomerulopathy.

原文英語
頁(從 - 到)1827-1829
頁數3
期刊Archives of Internal Medicine
146
發行號9
DOIs
出版狀態已發佈 - 十一月 26 1986
對外發佈Yes

ASJC Scopus subject areas

  • Internal Medicine

指紋 深入研究「Nephrotic syndrome associated with a clonal T-cell leukemia of large granular lymphocytes with cytotoxic function」主題。共同形成了獨特的指紋。

  • 引用此