Nephrotic Syndrome Associated With a Clonal T-Cell Leukemia of Large Granular Lymphocytes With Cytotoxic Function

Stephen V. Orman, Geraldine P. Schechter, Jacqueline Whang Peng, John Guccion, Clara Chan, Richard S. Schulof, Robert J. Shalhoub

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

摘要

• A 51-year-old man presented with a T-cell leukemia of large granular lymphocytes and rapidly developed a nephrotic syndrome due to presumptive minimal-change glomerulopathy. The E-rosette+, la+ cells demonstrated cytotoxic activity similar to that of natural killer lymphocytes but lacked other T-subset markers, except that one third of them bore Fc(IgG) receptors. Cytogenetic analysis revealed loss of chromosome 10 and the translocation (1;10)(p11;q11) in all metaphases. Regression of the leukemia after chemotherapy was accompanied by a dramatic resolution of the nephrotic syndrome, suggesting that the activated granular lymphocytes induced the renal lesion. The close association of a clonal T-lymphoproliferative disorder with minimal-change nephrotic syndrome lends further support to current views implicating activated T cells or their products in the pathogenesis of this glomerulopathy.
原文英語
頁(從 - 到)1827-1829
頁數3
期刊Archives of Internal Medicine
146
發行號9
DOIs
出版狀態已發佈 - 一月 1 1986
對外發佈Yes

ASJC Scopus subject areas

  • Internal Medicine

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