Negative-regulatory role of calmodulin in the expression of interferon-beta gene

H. Y. Lin, H. R. Thacore

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
原文英語
頁(從 - 到)86-90
頁數5
期刊Journal of Biological Regulators and Homeostatic Agents
5
發行號3
出版狀態已發佈 - 1991
對外發佈Yes

指紋

trifluoperazine
interferon-beta
Trifluoperazine
Interferon-beta
calmodulin
Calmodulin
Sendai virus
Genes
antagonists
cell culture
genes
Cell Culture Techniques
Messenger RNA
synthesis

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

引用此文

@article{cdbe6df6a5e7478bb40c9af078429921,
title = "Negative-regulatory role of calmodulin in the expression of interferon-beta gene",
abstract = "Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.",
author = "Lin, {H. Y.} and Thacore, {H. R.}",
year = "1991",
language = "English",
volume = "5",
pages = "86--90",
journal = "Journal of Biological Regulators and Homeostatic Agents",
issn = "0393-974X",
publisher = "Biolife SAS",
number = "3",

}

TY - JOUR

T1 - Negative-regulatory role of calmodulin in the expression of interferon-beta gene

AU - Lin, H. Y.

AU - Thacore, H. R.

PY - 1991

Y1 - 1991

N2 - Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.

AB - Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.

UR - http://www.scopus.com/inward/record.url?scp=0025999125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025999125&partnerID=8YFLogxK

M3 - Article

C2 - 1662459

AN - SCOPUS:0025999125

VL - 5

SP - 86

EP - 90

JO - Journal of Biological Regulators and Homeostatic Agents

JF - Journal of Biological Regulators and Homeostatic Agents

SN - 0393-974X

IS - 3

ER -