摘要
Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 86-90 |
| 頁數 | 5 |
| 期刊 | Journal of Biological Regulators and Homeostatic Agents |
| 卷 | 5 |
| 發行號 | 3 |
| 出版狀態 | 已發佈 - 1991 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Physiology (medical)
- Medicine (miscellaneous)
- Physiology
- Agricultural and Biological Sciences(all)
引用此
Lin, H. Y., & Thacore, H. R. (1991). Negative-regulatory role of calmodulin in the expression of interferon-beta gene. Journal of Biological Regulators and Homeostatic Agents, 5(3), 86-90.