Negative-regulatory role of calmodulin in the expression of interferon-beta gene

H. Y. Lin, H. R. Thacore

研究成果: 雜誌貢獻 › 文章

1 引文 (Scopus)

摘要

Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
原文英語
頁（從 - 到）86-90
頁數5
期刊Journal of Biological Regulators and Homeostatic Agents
卷5
發行號3
出版狀態已發佈 - 1991
對外發佈Yes

指紋

trifluoperazine
interferon-beta
Trifluoperazine
Interferon-beta
calmodulin
Calmodulin
Sendai virus
Genes
antagonists
cell culture
genes
Cell Culture Techniques
Messenger RNA
synthesis

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

引用此文

Negative-regulatory role of calmodulin in the expression of interferon-beta gene. / Lin, H. Y.; Thacore, H. R.

於: Journal of Biological Regulators and Homeostatic Agents, 卷 5, 編號 3, 1991, p. 86-90.

研究成果: 雜誌貢獻 › 文章

Lin, HY & Thacore, HR 1991, 'Negative-regulatory role of calmodulin in the expression of interferon-beta gene', Journal of Biological Regulators and Homeostatic Agents, 卷 5, 編號 3, 頁 86-90.
Lin HY, Thacore HR. Negative-regulatory role of calmodulin in the expression of interferon-beta gene. Journal of Biological Regulators and Homeostatic Agents. 1991;5(3):86-90.
Lin, H. Y. ; Thacore, H. R. / Negative-regulatory role of calmodulin in the expression of interferon-beta gene. 於: Journal of Biological Regulators and Homeostatic Agents. 1991 ; 卷 5, 編號 3. 頁 86-90.
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