Negative-regulatory role of calmodulin in the expression of interferon-beta gene

H. Y. Lin, H. R. Thacore

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
原文英語
頁(從 - 到)86-90
頁數5
期刊Journal of Biological Regulators and Homeostatic Agents
5
發行號3
出版狀態已發佈 - 1991
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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