Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
|頁（從 - 到）||86-90|
|期刊||Journal of Biological Regulators and Homeostatic Agents|
|出版狀態||已發佈 - 1991|
ASJC Scopus subject areas
- 農業與生物科學 (全部)