@article{6cdc4772b7434288b8a48fe3a05be337,
title = "Near-infrared-driven photoablation of lung cancer tumors utilizing biomimetic platelet-polyethyleneimine-polypyrrole drug-free nanoparticles",
abstract = "Platelets have unique properties that can be used in a variety of clinical settings. Their ability to target and accumulate in the lung cancer microenvironment can be exploited as a therapeutic targeted delivery method. In this study, we developed a drug-free biomimetic platelet-polyethyleneimine polypyrrole (PLT-PEI-PPY) conjugate that expresses epidermal growth factor (EGF) as a novel receptor-mediated material for efficient photothermal near-infrared (NIR) irradiation-hyperthermia and lung tumor ablation therapy. A neutral charge, photothermal response, and serum stability were discovered to be unique physiochemical features of this material. The PLT-PEI-PPY nanoparticles selectively aggregated in lung cancer cells in vitro and in vivo and had an anticancer impact via EGF receptor-mediated cancer cell endocytosis. In vivo, systemic injection of the platelet-PPY nanomaterial into mice was found to be safe and could fool the innate macrophage recognition system allowing to extend the residence time, and to improve the distribution to lung tumor tissues and the photothermal therapeutic efficacy under NIR illumination. By attaching photothermally responsive PEI-PPY nanoparticles to platelet membranes and exposing them to NIR irradiation, targeted ablation of lung malignancies was made possible. This nanoformulation, free of hazardous anticancer drugs, demonstrated a safer and more-effective bio-inspired photothermal-driven ablation therapy for lung cancer.",
keywords = "Epidermal growth factor, Human platelet pellet, Nano-hyperthermia, Prolonged delivery, Stealth properties",
author = "Thierry Burnouf and Jheng, {Pei Ru} and Chen, {Yun Hsuan} and Lekha Rethi and Lekha Rethi and Lu, {Long Sheng} and Ho, {Yi Cheng} and Chuang, {Er Yuan}",
note = "Funding Information: This work was supported by the Ministry of Science and Technology (MOST) of Taiwan [grant nos. 108-2221-E-038-017-MY3, 108-2320-B-038-061-MY3, 108-2636-E-038-001104 and 2314-B-038-040-MY3] and by grant NHRI-EX111-10920EI from the National Health Research Institute (NHRI) of Taiwan. Funding Information: We thank the Taipei Blood Center for the supply of the PLT concentrates. In vitro and in vivo research was carried out by Pei-Ru Jheng. Material analysis and in vitro cell tests were carried out by Yun-Hsuan Chen and Lekshmi Rethi. Lekha Rethi designed the schematic illustration and carried out the material and in vitro analysis. The study was designed by Thierry Burnouf and Er-Yuan Chuang, who also wrote the manuscript. Long-Sheng Lu assisted in the design of the in vivo experiments and also provided clinical interpretations. Thierry Burnouf and Pei-Ru Jheng contributed equally to this work. The molecular dynamic simulation was carried out by Yi-Cheng Ho. The final text was reviewed and approved by all the authors. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = mar,
doi = "10.1016/j.matdes.2022.110481",
language = "English",
volume = "215",
journal = "International Journal of Materials in Engineering Applications",
issn = "0261-3069",
publisher = "Elsevier BV",
}
