Nationwide surveillance of antimicrobial resistance among haemophilus influenzae and streptococcus pneumoniae in intensive care units in Taiwan

S. S. Jean, P. R. Hsueh, W. S. Lee, H. T. Chang, M. Y. Chou, I. S. Chen, J. H. Wang, C. F. Lin, J. M. Shyr, W. C. Ko, J. J. Wu, Y. C. Liu, W. K. Huang, L. J. Teng, C. Y. Liu

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19 引文 斯高帕斯(Scopus)

摘要

A nationwide susceptibility surveillance of Streptococcus pneumoniae and Haemophilus influenzae isolates collected from patients treated at the intensive care units (ICUs) of ten Taiwanese major teaching hospitals was conducted from September 2005 through November 2005. High rates of resistance (intermediate/resistant) of S. pneumoniae to penicillin (85% resistance), ceftriaxone (46%/20%), and cefepime (43%/15%) by meningitis criteria, and in contrast, non-susceptibilities (intermediate/resistant) to penicillin (0%/0%), ceftriaxone (20%/0%) and cefepime (15%/0%) by non-meningitis criteria were noted (p values < 0.05) by the Clinical and Laboratory Standards Institute 2008. Resistant rate of S. pneumoniae to azithromycin was also high (63%). S. pneumoniae isolates were significantly more susceptible to ertapenem (87%) than to imipenem (39%) and meropenem (44%) (p values < 0.05). Rates of non-susceptibilities of H. influenzae isolates to ampicillin and cefaclor were high (55% and 45%, respectively). No β-lactamase-negative ampicillin-resistant (BLNAR) H. influenzae isolates were found. Imipenem has a notably higher MIC90 value (8 μg/ml) for H. influenzae than that of the other two carbapenems. Tigecycline showed good in vitro activities against these two respiratory pathogens. High rates of resistance among isolates of S. pneumoniae and H. influenzae continue to exist in the ICUs of Taiwan.

原文英語
頁(從 - 到)1013-1017
頁數5
期刊European Journal of Clinical Microbiology and Infectious Diseases
28
發行號8
DOIs
出版狀態已發佈 - 8月 2009
對外發佈

ASJC Scopus subject areas

  • 微生物學(醫學)
  • 傳染性疾病

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