NAT2*7 allele is a potential risk factor for adult brain tumors in Taiwanese population

H. Eugene Liu, Pei Yu Hsiao, Ching Chen Lee, Jen Ai Lee, Hsiang Yin Chen

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7 引文 斯高帕斯(Scopus)

摘要

Arylamine N-acetyltransferase-2 (NAT2) displays extensive genetic polymorphisms that affect the rates of acetylation of drugs and toxic compounds such as amine carcinogens. The association of NAT2 polymorphisms with adult brain tumors has been unclear. To investigate whether the NAT2 genotype is a risk factor of brain tumors, we determined the frequencies of three common polymorphisms in the NAT2 gene, NAT2*5 (T341C), NAT2*6 (G590A), and NAT2*7(G857A), in brain tumor patients and in age- and gender-matched control subjects (n = 27 in each group). Genotyping was carried out using PCR-RFLP and subjects were phenotyped as a fast or slow acetylator based on the genotypes. The odds ratio of NAT2*7 allele frequency was significantly higher in patients with brain tumor than in controls (odds ratio, 6.786; 95% confidence interval, 2.06-22.37; P = 0.003); in the mean time, NAT2*4/*7 genotype was significantly more common in the patient group than in controls (odds ratio, 6.19; 95% confidence interval, 1.68-22.79; P = 0.0039). The tumors in the patients with NAT2*7 allele tended to be high-grade astrocytoma or glioblastoma multiforme (P = 0.016). In conclusion, these data suggest that the presence of NAT2*7 allele might be a potential risk factor for the development of brain tumors in Taiwan.
原文英語
頁(從 - 到)661-665
頁數5
期刊Cancer Epidemiology Biomarkers and Prevention
17
發行號3
DOIs
出版狀態已發佈 - 3月 2008

ASJC Scopus subject areas

  • 流行病學
  • 腫瘤科

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