NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan

Hui Ling Chiou, Ming Fang Wu, Wen Pin Chien, Ya Wen Cheng, Ruey Hong Wong, Chin Yi Chen, Torng Sen Lin, Huei Lee

研究成果: 雜誌貢獻文章同行評審

38 引文 斯高帕斯(Scopus)

摘要

The correlation between cooking oil fumes, containing relatively higher amounts of heterocyclic amines, and female lung cancer has been revealed. The association of genetic polymorphisms of CYP1A2 and NAT2, two major enzymes responsible for the metabolism of heterocyclic amines, with lung cancer has been investigated with inconclusive results. In this study targeted on never-smoking population with 162 lung cancer patients and 208 non-cancer controls, while the distributions of CYP1A2 phenotypes in lung cancer patients were comparable to that in controls, NAT2 fast acetylators had an OR of 2.44 (95% CI 1.40-4.23, P=0.002) and 2.56 (95% CI 1.37-4.80, P=0.003) for lung cancer in overall and female cases, respectively, but not in males. These results suggested never-smoking females with NAT2 fast acetylator were more prone to lung cancer and reflected the possibility that exposure to heterocyclic amines may contribute to the female lung cancer development in Taiwan.
原文英語
頁(從 - 到)93-101
頁數9
期刊Cancer Letters
223
發行號1
DOIs
出版狀態已發佈 - 六月 1 2005
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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