Naphthoflavones as antiproliferative agents: Design, synthesis and biological evaluation

Dinesh Kumar, Onkar Singh, Kunal Nepali, P. M.S. Bedi, Arem Qayum, Shashank Singh, Subheet K. Jain

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

The present study involves the design and synthesis of naphthoflavones as antiproliferative agents. The strategy presents naphthoflavones as hybrids of naphthyl based chalcones and flavones. A panel of human cancer cell lines were employed for the cytotoxicity studies. DK-13 exhibited significant cytoxicity against MiaPaCa-2 cell lines with IC50 value of 1.93 μM and 5.63 μM against MCF-7 cell lines. The compound DK-13 was found to induce apoptosis evidenced through phase contrast microscopy, DAPI staining, and mitochondrial membrane potential loss. The cell phase distribution studies indicated an increase from 11.26% (control sample) to 55.19% (sample treated with 20 μM compound DK-13) in the apoptotic population.
原文英語
頁(從 - 到)881-890
頁數10
期刊Anti-Cancer Agents in Medicinal Chemistry
16
發行號7
DOIs
出版狀態已發佈 - 七月 1 2016
對外發佈Yes

指紋

Cell Line
Chalcones
Flavones
Phase-Contrast Microscopy
Mitochondrial Membrane Potential
MCF-7 Cells
Inhibitory Concentration 50
Apoptosis
Staining and Labeling
Population
Neoplasms
DAPI
compound 20

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

引用此文

Naphthoflavones as antiproliferative agents : Design, synthesis and biological evaluation. / Kumar, Dinesh; Singh, Onkar; Nepali, Kunal; Bedi, P. M.S.; Qayum, Arem; Singh, Shashank; Jain, Subheet K.

於: Anti-Cancer Agents in Medicinal Chemistry, 卷 16, 編號 7, 01.07.2016, p. 881-890.

研究成果: 雜誌貢獻文章

Kumar, Dinesh ; Singh, Onkar ; Nepali, Kunal ; Bedi, P. M.S. ; Qayum, Arem ; Singh, Shashank ; Jain, Subheet K. / Naphthoflavones as antiproliferative agents : Design, synthesis and biological evaluation. 於: Anti-Cancer Agents in Medicinal Chemistry. 2016 ; 卷 16, 編號 7. 頁 881-890.
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