Nano/sub-microsized lignan glycosides from sesame meal exhibit higher transport and absorption efficiency in Caco-2 cell monolayer

Chia Ding Liao, Wei Lun Hung, Kuo Ching Jan, An I. Yeh, Chi Tang Ho, Lucy Sun Hwang

研究成果: 雜誌貢獻文章

39 引文 斯高帕斯(Scopus)

摘要

In the present study, we investigated whether lignan glycosides from sesame meal (LGSM), after nano/sub-microsizing, will exhibit higher transport and absorption efficiencies than LGSM. The average particle size of 1% LGSM aqueous suspension reduced from approximately 2 μm-200 nm after media-milling with zirconia beads. The transport and absorption of LGSM and nano/sub-microsized LGSM (N-LGSM) using Caco-2 human epithelial colorectal adenocarcinoma cells, a model simulating human intestinal absorption was examined. The permeability of sesaminol triglucoside (ST) in N-LGSM and LGSM was 1.41 ± 0.16 and 1.07 ± 0.21 (10-6 cm/s), respectively, indicating that ST in N-LGSM was more efficiently transported through the monolayer. In addition, N-LGSM exhibited 35.7% higher absorption efficiency than LGSM. The better performance of N-LGSM may be attributed to the (a) smaller particle size and larger surface area; (b) increased mucosal permeability, and (c) improved intestinal absorption due to the formation of nanoemulsion droplets.
原文英語
頁(從 - 到)896-902
頁數7
期刊Food Chemistry
119
發行號3
DOIs
出版狀態已發佈 - 四月 1 2010
對外發佈Yes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science
  • Medicine(all)

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