Nanostructured titanium dioxide layer combined with reactive functional groups as a promising biofunctional surface for biomedical applications

Chi Ming Wu, Chung Ming Liu, Keng Liang Ou, Hsi Jen Chiang, Erwan Sugiatno, Chia Hung Wu, Hsiu Ju Yen, Hsin Hua Chou

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

In the present study, low-temperature plasma combined with allylamine polymerization approach was used to coat amino-groups on oxide layer of plasma-oxidized biomedical titanium (Ti) for protein immobilization. Scanning electron microscopy, X-ray diffractometer, transmission electron microscopy, X-ray photoemission spectroscopy, secondary ion mass spectrometer and 2, 4, 6-trinitrobenzenesulfonic acid assay were utilized to investigate the surface and microstructural properties of the plasma-oxidized, plasma-polymerized and protein-immobilized samples. Analytical results indicated that the presence of a nanostructured rutile-TiO 2 thin layer could be found on the plasma-oxidized samples. The thickness of nanostructured rutile-TiO 2 layer increased with increasing plasma treatment power and period. As the plasma-oxidized samples underwent plasma polymerization with allylamine, amino-groups (NH 2 ) were uniformly coated on nanostructured rutile-TiO 2 layer. It was also found that Ti surface with thick oxide layer exhibited higher amounts of amino-groups deposition. After protein immobilization, the plasma-polymerized samples presented a formation of uniform streak-like immobilized protein clusters. Therefore, biomedical Ti with nanostructured rutile-TiO 2 layer is a promising biomaterial that can be applied to cross-link with other biomolecules for promoting the bone healing and regeneration.
原文英語
頁(從 - 到)9712-9718
頁數7
期刊Ceramics International
45
發行號8
DOIs
出版狀態已發佈 - 六月 1 2019

ASJC Scopus subject areas

  • 電子、光磁材料
  • 陶瓷和複合材料
  • 製程化學與技術
  • 表面、塗料和薄膜
  • 材料化學

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