Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications

Hsiao Lan Pu, Wei Lun Chiang, Barnali Maiti, Zi Xian Liao, Yi Cheng Ho, Min Suk Shim, Er-Tuan Chuang, Younan Xia, Hsing Wen Sung

研究成果: 雜誌貢獻文章同行評審

103 引文 斯高帕斯(Scopus)

摘要

Oxidative stress and reduced pH are involved in many inflammatory diseases. This study describes a nanoparticle-based system that is responsive to both oxidative stress and reduced pH in an inflammatory environment to effectively release its encapsulated curcumin, an immune-modulatory agent with potent anti-inflammatory and antioxidant capabilities. Because of the presence of Förster resonance energy transfer between curcumin and the carrier, this system also allowed us to monitor the intracellular release behavior. The curcumin released upon triggering could efficiently reduce the excess oxidants produced by the lipopolysaccharide (LPS)-stimulated macrophages. The feasibility of using the curcumin-loaded nanoparticles for anti-inflammatory applications was further validated in a mouse model with ankle inflammation induced by LPS. The results of these studies demonstrate that the proposed nanoparticle system is promising for treating oxidative stress-related diseases.
原文英語
頁(從 - 到)1213-1221
頁數9
期刊ACS Nano
8
發行號2
DOIs
出版狀態已發佈 - 二月 25 2014
對外發佈Yes

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

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