Nanoformulation properties, characterization, and behavior in complex biological matrices

Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential

Vibhuti Agrahari, Pierre Alain Burnouf, Thierry Burnouf, Vivek Agrahari

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic indications, including neurodegenerative disorders. A broader understanding of the impact of nanomedicines design is now required to enhance their translational potential. Nanoformulations in vivo journey is significantly affected by their physicochemical properties including the size, shape, hydrophobicity, elasticity, and surface charge/chemistry/morphology, which play a role as an interface with the biological environment. Understanding protein corona formation is crucial in characterizing nanocarriers and evaluating their interactions with biological systems. In this review, the types and properties of the brain-targeted nanocarriers are discussed. The biological factors and nanocarriers properties affecting their in vivo behavior are elaborated. The compositional description of cell culture and biological matrices, including proteins potentially relevant to protein corona built-up on nanoformulation especially for brain administration, is provided. Analytical techniques of characterizing nanocarriers in complex matrices, their advantages, limitations, and implementation challenges in industrial GMP environment are discussed. The uses of orthogonal complementary characterization approaches of nanocarriers are also covered.
原文英語
期刊Advanced Drug Delivery Reviews
DOIs
出版狀態已發佈 - 一月 1 2019

指紋

Nanomedicine
Artificial Cells
Elasticity
Brain
Biological Factors
Hydrophobic and Hydrophilic Interactions
Neurodegenerative Diseases
Pharmaceutical Preparations
Cell Culture Techniques
Proteins
Protein Corona
Therapeutics

Keywords

  • Biological proteins
  • Blood-brain barrier
  • Cell-based nanocarrier
  • Neurodegenerative disorders
  • Cell-culture media
  • Characterization methods
  • Nanoparticles
  • Physicochemical properties
  • Protein-corona

ASJC Scopus subject areas

  • Pharmaceutical Science

引用此文

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abstract = "Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic indications, including neurodegenerative disorders. A broader understanding of the impact of nanomedicines design is now required to enhance their translational potential. Nanoformulations in vivo journey is significantly affected by their physicochemical properties including the size, shape, hydrophobicity, elasticity, and surface charge/chemistry/morphology, which play a role as an interface with the biological environment. Understanding protein corona formation is crucial in characterizing nanocarriers and evaluating their interactions with biological systems. In this review, the types and properties of the brain-targeted nanocarriers are discussed. The biological factors and nanocarriers properties affecting their in vivo behavior are elaborated. The compositional description of cell culture and biological matrices, including proteins potentially relevant to protein corona built-up on nanoformulation especially for brain administration, is provided. Analytical techniques of characterizing nanocarriers in complex matrices, their advantages, limitations, and implementation challenges in industrial GMP environment are discussed. The uses of orthogonal complementary characterization approaches of nanocarriers are also covered.",
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