Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Shan Jen Lin, Yu Tang Chin, Yih Ho, Szu Yi Chou, Yu Chen Sh Yang, André Wendindondé Nana, Kuan Wei Su, Yee Tong Lim, Kuan Wang, Sheng‐Yang Y. Lee, Ya Jung Shih, Yi Ru Chen, Jacqueline Whang-Peng, Paul J. Davis, Hung Yun Lin, Earl Fu

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)


Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.
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期刊Food and Chemical Toxicology
出版狀態已發佈 - 十月 1 2018


ASJC Scopus subject areas

  • Food Science
  • Toxicology