Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Shan Jen Lin, Yu Tang Chin, Yih Ho, Szu Yi Chou, Yu Chen Sh Yang, André Wendindondé Nana, Kuan Wei Su, Yee Tong Lim, Kuan Wang, Sheng‐Yang Y. Lee, Ya Jung Shih, Yi Ru Chen, Jacqueline Whang-Peng, Paul J. Davis, Hung Yun Lin, Earl Fu

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.
原文英語
頁(從 - 到)1-11
頁數11
期刊Food and Chemical Toxicology
120
DOIs
出版狀態已發佈 - 十月 1 2018

指紋

Mouth Neoplasms
Cells
death
Ligands
phosphatidylinositol 3-kinase
thyroid hormones
tetraiodothyroacetic acid
mouth neoplasms
ligands
neoplasm cells
Phosphatidylinositol 3-Kinases
Thyroid Hormones
Tumors
Neoplasms
Proteins
protein content
Messenger RNA
monitoring

ASJC Scopus subject areas

  • Food Science
  • Toxicology

引用此文

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. / Lin, Shan Jen; Chin, Yu Tang; Ho, Yih; Chou, Szu Yi; Sh Yang, Yu Chen; Nana, André Wendindondé; Su, Kuan Wei; Lim, Yee Tong; Wang, Kuan; Lee, Sheng‐Yang Y.; Shih, Ya Jung; Chen, Yi Ru; Whang-Peng, Jacqueline; Davis, Paul J.; Lin, Hung Yun; Fu, Earl.

於: Food and Chemical Toxicology, 卷 120, 01.10.2018, p. 1-11.

研究成果: 雜誌貢獻文章

Lin, Shan Jen ; Chin, Yu Tang ; Ho, Yih ; Chou, Szu Yi ; Sh Yang, Yu Chen ; Nana, André Wendindondé ; Su, Kuan Wei ; Lim, Yee Tong ; Wang, Kuan ; Lee, Sheng‐Yang Y. ; Shih, Ya Jung ; Chen, Yi Ru ; Whang-Peng, Jacqueline ; Davis, Paul J. ; Lin, Hung Yun ; Fu, Earl. / Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. 於: Food and Chemical Toxicology. 2018 ; 卷 120. 頁 1-11.
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abstract = "Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.",
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AU - Sh Yang, Yu Chen

AU - Nana, André Wendindondé

AU - Su, Kuan Wei

AU - Lim, Yee Tong

AU - Wang, Kuan

AU - Lee, Sheng‐Yang Y.

AU - Shih, Ya Jung

AU - Chen, Yi Ru

AU - Whang-Peng, Jacqueline

AU - Davis, Paul J.

AU - Lin, Hung Yun

AU - Fu, Earl

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AB - Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.

KW - NDAT

KW - Oral cancer

KW - PD-L1

KW - Proliferation

KW - Thyroxine

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