Myocardial Regional Interstitial Fibrosis is Associated with Left Intra-Ventricular Dyssynchrony in Patients with Heart Failure: A Cardiovascular Magnetic Resonance Study

Lian Yu Lin, Cho Kai Wu, Jyh Ming Jimmy Juang, Yi Chih Wang, Mao Yuan Marine Su, Ling Ping Lai, Juey Jen Hwang, Fu Tien Chiang, Wen Yih Issac Tseng, Jiunn Lee Lin

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-Two patients with systolic heart failure (SHF), 76 patients with heart failure with preserved ejection fraction (HFpEF) and 20 patients without HF received cardiovascular magnetic resonance imaging (MRI) study. LV was divided into 18 segments by short-Axis view. In each segment, regional extracellular volume fraction (ECV) and the time taken to reach minimum regional volume (Tmv) were derived. Intra-LV dyssynchrony were represented by maximum difference (Dysynmax) and standard deviation (Dysynsd) of all Tmv. The results showed that among the covariates, only age (1.87, 95% CI: 0.61-3.13, p = 0.004) and ECV (3.77, 95% CI: 2.72-4.81, p < 0.001) were positively associated with Tmv. The results remained robust in certain subgroups. In conclusion, we demonstrated that LV myocardium regional variation in interstitial fibrosis is closely related to LV intra-ventricular dyssynchrony irrespective of the LV global function. These data might help explain the pathophysiology of LV dyssynchrony and itâ € s underlying mechanisms leading to poor prognosis.
原文英語
文章編號20711
期刊Scientific Reports
6
DOIs
出版狀態已發佈 - 二月 5 2016
對外發佈Yes

指紋

Fibrosis
Magnetic Resonance Spectroscopy
Heart Failure
Myocardium
Systolic Heart Failure
Left Ventricular Function
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • General

引用此文

Myocardial Regional Interstitial Fibrosis is Associated with Left Intra-Ventricular Dyssynchrony in Patients with Heart Failure : A Cardiovascular Magnetic Resonance Study. / Lin, Lian Yu; Wu, Cho Kai; Juang, Jyh Ming Jimmy; Wang, Yi Chih; Su, Mao Yuan Marine; Lai, Ling Ping; Hwang, Juey Jen; Chiang, Fu Tien; Tseng, Wen Yih Issac; Lin, Jiunn Lee.

於: Scientific Reports, 卷 6, 20711, 05.02.2016.

研究成果: 雜誌貢獻文章

Lin, Lian Yu ; Wu, Cho Kai ; Juang, Jyh Ming Jimmy ; Wang, Yi Chih ; Su, Mao Yuan Marine ; Lai, Ling Ping ; Hwang, Juey Jen ; Chiang, Fu Tien ; Tseng, Wen Yih Issac ; Lin, Jiunn Lee. / Myocardial Regional Interstitial Fibrosis is Associated with Left Intra-Ventricular Dyssynchrony in Patients with Heart Failure : A Cardiovascular Magnetic Resonance Study. 於: Scientific Reports. 2016 ; 卷 6.
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abstract = "Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-Two patients with systolic heart failure (SHF), 76 patients with heart failure with preserved ejection fraction (HFpEF) and 20 patients without HF received cardiovascular magnetic resonance imaging (MRI) study. LV was divided into 18 segments by short-Axis view. In each segment, regional extracellular volume fraction (ECV) and the time taken to reach minimum regional volume (Tmv) were derived. Intra-LV dyssynchrony were represented by maximum difference (Dysynmax) and standard deviation (Dysynsd) of all Tmv. The results showed that among the covariates, only age (1.87, 95{\%} CI: 0.61-3.13, p = 0.004) and ECV (3.77, 95{\%} CI: 2.72-4.81, p < 0.001) were positively associated with Tmv. The results remained robust in certain subgroups. In conclusion, we demonstrated that LV myocardium regional variation in interstitial fibrosis is closely related to LV intra-ventricular dyssynchrony irrespective of the LV global function. These data might help explain the pathophysiology of LV dyssynchrony and it{\^a} € s underlying mechanisms leading to poor prognosis.",
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AU - Wang, Yi Chih

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