Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41

W. R. Lee; X. F. Yu; W. J. Syu; M. Essex; T. H. Lee

doi:10.1128/jvi.66.3.1799-1803.1992

Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41

W. R. Lee, X. F. Yu, W. J. Syu, M. Essex, T. H. Lee

研究成果: 雜誌貢獻 › 評論/辯論 › 同行評審

40 引文斯高帕斯（Scopus）

摘要

Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.

原文	英語
頁（從 - 到）	1799-1803
頁數	5
期刊	Journal of Virology
卷	66
發行號	3
DOIs	https://doi.org/10.1128/jvi.66.3.1799-1803.1992
出版狀態	已發佈 - 1992

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.66.3.1799-1803.1992

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引用此

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