Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41

W. R. Lee, X. F. Yu, W. J. Syu, M. Essex, T. H. Lee

研究成果: 雜誌貢獻評論/辯論同行評審

40 引文 斯高帕斯(Scopus)

摘要

Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.
原文英語
頁(從 - 到)1799-1803
頁數5
期刊Journal of Virology
66
發行號3
DOIs
出版狀態已發佈 - 1992

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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