Mutagenicity study of butachlor and its metabolites using Salmonella typhimurium

Kuei Yao Hsu, Hwai Jeng Lin, Jen Kun Lin, Wein Shung Kuo, Yueh Hsing Ou

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

Butachlor is the most commonly used herbicide in Taiwan and many other countries. It has been reported to be an indirect mutagen and carcinogen in various in vitro assay systems. Previous investigation has also demonstrated that butachlor stimulates cell proliferation, transforms normal embryonic cells, and induces stomach tumors in Spraque-Dawley rats. However, the mechanism of butachlor carcinogenicity is still not clear. In order to clarify the toxicologic and carcinogenic properties of butachlor, we proposed a metabolic pathway, and synthesized the authentic metabolites by chemical methods. In addition, we tested the mutagenicity of butachlor and these metabolites on Salmonella typhimurium. The results indicate that butachlor might manifest its carcinogenicity via the mutagenicity of its metabolic products. Although the molecular mechanism of butachlor-induced cellular toxicity is still not clear, it is likely that the cellular transformation ability of butachlor is partly associated with its mutagenicity.

原文英語
頁(從 - 到)409-416
頁數8
期刊Journal of Microbiology, Immunology and Infection
38
發行號6
出版狀態已發佈 - 12月 2005
對外發佈

ASJC Scopus subject areas

  • 微生物學(醫學)
  • 免疫學和過敏
  • 免疫學與微生物學 (全部)

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