TY - JOUR
T1 - Multiple roles of RBM4 in muscle cell differentiation
AU - Lin, Jung Chun
AU - Tarn, Woan Yuh
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Muscle cell differentiation involves gene regulation at both transcriptional and post-transcriptional steps. Post-transcriptional control requires various RNA binding proteins. The multi-functional RNA binding motif 4 (RBM4) protein participates in both precursor mRNA splicing regulation and translational control in muscle cells. In myoblasts, RBM4 promotes the expression of many muscle-specific mRNAs from individual genes via its activity in modulating alternative splicing. In addition, RBM4 transiently translocates to the cytoplasm during myogenesis, where it participates in translation control. RBM4 may act in conjunction with a subset of musclespecific microRNAs to modulate their activity in translation suppression. Overexpression of RBM4 promotes muscle cell differentiation, suggesting that RBM4 acts as a positive myogenic regulator. In this review, we discuss recent data regarding how RBM4 may foster muscle cell differentiation.
AB - Muscle cell differentiation involves gene regulation at both transcriptional and post-transcriptional steps. Post-transcriptional control requires various RNA binding proteins. The multi-functional RNA binding motif 4 (RBM4) protein participates in both precursor mRNA splicing regulation and translational control in muscle cells. In myoblasts, RBM4 promotes the expression of many muscle-specific mRNAs from individual genes via its activity in modulating alternative splicing. In addition, RBM4 transiently translocates to the cytoplasm during myogenesis, where it participates in translation control. RBM4 may act in conjunction with a subset of musclespecific microRNAs to modulate their activity in translation suppression. Overexpression of RBM4 promotes muscle cell differentiation, suggesting that RBM4 acts as a positive myogenic regulator. In this review, we discuss recent data regarding how RBM4 may foster muscle cell differentiation.
KW - Alternative splicing
KW - Myogenesis
KW - Nonsense-mediated RNA decay
KW - RNA binding proteins
KW - Translation
UR - http://www.scopus.com/inward/record.url?scp=84883659798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883659798&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84883659798
VL - 4 S
SP - 181
EP - 189
JO - Frontiers in Bioscience - Scholar
JF - Frontiers in Bioscience - Scholar
SN - 1945-0516
IS - 1
ER -