Multiparametric mapping of white matter microstructure in catatonia

Jakob Wasserthal, Klaus H. Maier-Hein, Peter F. Neher, Georg Northoff, Katharina M. Kubera, Stefan Fritze, Anais Harneit, Lena S. Geiger, Heike Tost, Robert C. Wolf, Dusan Hirjak

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Catatonia is characterized by motor, affective and behavioral abnormalities. To date, the specific role of white matter (WM) abnormalities in schizophrenia spectrum disorders (SSD) patients with catatonia is largely unknown. In this study, diffusion magnetic resonance imaging (dMRI) data were collected from 111 right-handed SSD patients and 28 healthy controls. Catatonic symptoms were examined on the Northoff Catatonia Rating Scale (NCRS). We used whole-brain tract-based spatial statistics (TBSS), tractometry (along tract statistics using TractSeg) and graph analytics (clustering coefficient—CCO, local betweenness centrality—BC) to provide a framework of specific WM microstructural abnormalities underlying catatonia in SSD. Following a categorical approach, post hoc analyses showed differences in fractional anisotrophy (FA) measured via tractometry in the corpus callosum, corticospinal tract and thalamo-premotor tract as well as increased CCO as derived by graph analytics of the right superior parietal cortex (SPC) and left caudate nucleus in catatonic patients (NCRS total score ≥ 3; n = 30) when compared to non-catatonic patients (NCRS total score = 0; n = 29). In catatonic patients according to DSM-IV-TR (n = 43), catatonic symptoms were associated with FA variations (tractometry) of the left corticospinal tract and CCO of the left orbitofrontal cortex, primary motor cortex, supplementary motor area and putamen. This study supports the notion that structural reorganization of WM bundles connecting orbitofrontal/parietal, thalamic and striatal regions contribute to catatonia in SSD patients.

原文英語
頁(從 - 到)1750-1757
頁數8
期刊Neuropsychopharmacology
45
發行號10
DOIs
出版狀態已發佈 - 九月 1 2020

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

指紋 深入研究「Multiparametric mapping of white matter microstructure in catatonia」主題。共同形成了獨特的指紋。

  • 引用此

    Wasserthal, J., Maier-Hein, K. H., Neher, P. F., Northoff, G., Kubera, K. M., Fritze, S., Harneit, A., Geiger, L. S., Tost, H., Wolf, R. C., & Hirjak, D. (2020). Multiparametric mapping of white matter microstructure in catatonia. Neuropsychopharmacology, 45(10), 1750-1757. https://doi.org/10.1038/s41386-020-0691-2