Multifaceted regenerative lives of expired platelets in the second decade of the 21st century

Thierry Burnouf, Hadi Alphonse Goubran, Jerard Seghatchian

研究成果: 雜誌貢獻回顧型文獻

8 引文 斯高帕斯(Scopus)

摘要

A traditional concept in transfusion medicine is the expiration of platelet concentrates 5-7 days after collection due to storage conditions that favor the risks of bacterial contamination and may lead to a gradual alteration of platelet hemostatic power. Newer findings are strongly suggesting that, after their supposed expiration date, platelet concentrates still contain multiple functional growth factors and cytokines and actually have unaltered power for application in regenerative medicine and cell therapy. Expired platelets can be a valuable source of growth factors to promote the healing of wounds, and can be used for ex vivo expansion of stem cells. There is also preliminary evidence that infusible platelet membrane (IPM) from outdated platelet concentrates and thrombosomes have potential clinical applications as hemostatic products. Experimental work is certainly needed to further validate and standardize the clinical potential of "expired" platelet blood products in human clinical medicine. However, strong evidence accumulates toward a potential for further manufacturing avenues of expired platelet concentrates into valuable therapeutic and clinically relevant products.
原文英語
頁(從 - 到)107-112
頁數6
期刊Transfusion and Apheresis Science
51
發行號2
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

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