Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma

Chun Hsiung Chen, Chih Hsueh Chen, Horng An Chen, Hsien Tzung Liao, Hsiao Yi Lin

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Multicentric reticulohistiocytosis (MRH) is a rare multisystemic disease presenting with skin lesions and erosive polyarthritis and is often associated with malignancy. We describe a 60-year-old woman with diffuse papulonodular skin eruptions and progressive osteolytic bone damage over the bilateral hands, humeral head, and acromioclavicular joints within 2 years. Moreover, dysphagia and a hoarse voice occurred in this patient and an unusual huge mass-reticulohistiocytoma-developed over the left upper back. Tissue biopsy of the skin lesions, laryngeal nodules, and this large mass showed infiltration of numerous CD68(+) histiocytes and multinucleated giant cells with abundant eosinophilic ground-glass cytoplasm. Combination therapy with steroids and methotrexate improved her cutaneous, joint, and laryngopharyngeal symptoms. The large reticulohistiocytoma resolved with methylprednisolone pulse therapy. This polyarthritis, which can be confused with rheumatoid arthritis, can be diagnosed by careful immunohistochemical examination of biopsies. To prevent the irreversible disease process, early and aggressive therapy is necessary.

原文英語
頁(從 - 到)252-254
頁數3
期刊Journal of Clinical Rheumatology
12
發行號5
DOIs
出版狀態已發佈 - 十月 2006

指紋

Non-Langerhans-Cell Histiocytosis
Arthritis
Skin
Acromioclavicular Joint
Humeral Head
Biopsy
Histiocytes
Methylprednisolone
Giant Cells
Deglutition Disorders
Rare Diseases
Secondary Prevention
Methotrexate
Glass
Rheumatoid Arthritis
Cytoplasm
Hand
Joints
Steroids
Bone and Bones

ASJC Scopus subject areas

  • Rheumatology

引用此文

Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma. / Chen, Chun Hsiung; Chen, Chih Hsueh; Chen, Horng An; Liao, Hsien Tzung; Lin, Hsiao Yi.

於: Journal of Clinical Rheumatology, 卷 12, 編號 5, 10.2006, p. 252-254.

研究成果: 雜誌貢獻文章

Chen, Chun Hsiung ; Chen, Chih Hsueh ; Chen, Horng An ; Liao, Hsien Tzung ; Lin, Hsiao Yi. / Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma. 於: Journal of Clinical Rheumatology. 2006 ; 卷 12, 編號 5. 頁 252-254.
@article{1269a02662114dd5a84110ebc852d3c6,
title = "Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma",
abstract = "Multicentric reticulohistiocytosis (MRH) is a rare multisystemic disease presenting with skin lesions and erosive polyarthritis and is often associated with malignancy. We describe a 60-year-old woman with diffuse papulonodular skin eruptions and progressive osteolytic bone damage over the bilateral hands, humeral head, and acromioclavicular joints within 2 years. Moreover, dysphagia and a hoarse voice occurred in this patient and an unusual huge mass-reticulohistiocytoma-developed over the left upper back. Tissue biopsy of the skin lesions, laryngeal nodules, and this large mass showed infiltration of numerous CD68(+) histiocytes and multinucleated giant cells with abundant eosinophilic ground-glass cytoplasm. Combination therapy with steroids and methotrexate improved her cutaneous, joint, and laryngopharyngeal symptoms. The large reticulohistiocytoma resolved with methylprednisolone pulse therapy. This polyarthritis, which can be confused with rheumatoid arthritis, can be diagnosed by careful immunohistochemical examination of biopsies. To prevent the irreversible disease process, early and aggressive therapy is necessary.",
keywords = "Multicentric reticulohistiocytosis, Nasopharyngeal dysfunction, Polyarthritis",
author = "Chen, {Chun Hsiung} and Chen, {Chih Hsueh} and Chen, {Horng An} and Liao, {Hsien Tzung} and Lin, {Hsiao Yi}",
year = "2006",
month = "10",
doi = "10.1097/01.rhu.0000239902.91768.f9",
language = "English",
volume = "12",
pages = "252--254",
journal = "Journal of Clinical Rheumatology",
issn = "1076-1608",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma

AU - Chen, Chun Hsiung

AU - Chen, Chih Hsueh

AU - Chen, Horng An

AU - Liao, Hsien Tzung

AU - Lin, Hsiao Yi

PY - 2006/10

Y1 - 2006/10

N2 - Multicentric reticulohistiocytosis (MRH) is a rare multisystemic disease presenting with skin lesions and erosive polyarthritis and is often associated with malignancy. We describe a 60-year-old woman with diffuse papulonodular skin eruptions and progressive osteolytic bone damage over the bilateral hands, humeral head, and acromioclavicular joints within 2 years. Moreover, dysphagia and a hoarse voice occurred in this patient and an unusual huge mass-reticulohistiocytoma-developed over the left upper back. Tissue biopsy of the skin lesions, laryngeal nodules, and this large mass showed infiltration of numerous CD68(+) histiocytes and multinucleated giant cells with abundant eosinophilic ground-glass cytoplasm. Combination therapy with steroids and methotrexate improved her cutaneous, joint, and laryngopharyngeal symptoms. The large reticulohistiocytoma resolved with methylprednisolone pulse therapy. This polyarthritis, which can be confused with rheumatoid arthritis, can be diagnosed by careful immunohistochemical examination of biopsies. To prevent the irreversible disease process, early and aggressive therapy is necessary.

AB - Multicentric reticulohistiocytosis (MRH) is a rare multisystemic disease presenting with skin lesions and erosive polyarthritis and is often associated with malignancy. We describe a 60-year-old woman with diffuse papulonodular skin eruptions and progressive osteolytic bone damage over the bilateral hands, humeral head, and acromioclavicular joints within 2 years. Moreover, dysphagia and a hoarse voice occurred in this patient and an unusual huge mass-reticulohistiocytoma-developed over the left upper back. Tissue biopsy of the skin lesions, laryngeal nodules, and this large mass showed infiltration of numerous CD68(+) histiocytes and multinucleated giant cells with abundant eosinophilic ground-glass cytoplasm. Combination therapy with steroids and methotrexate improved her cutaneous, joint, and laryngopharyngeal symptoms. The large reticulohistiocytoma resolved with methylprednisolone pulse therapy. This polyarthritis, which can be confused with rheumatoid arthritis, can be diagnosed by careful immunohistochemical examination of biopsies. To prevent the irreversible disease process, early and aggressive therapy is necessary.

KW - Multicentric reticulohistiocytosis

KW - Nasopharyngeal dysfunction

KW - Polyarthritis

UR - http://www.scopus.com/inward/record.url?scp=33749535747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749535747&partnerID=8YFLogxK

U2 - 10.1097/01.rhu.0000239902.91768.f9

DO - 10.1097/01.rhu.0000239902.91768.f9

M3 - Article

C2 - 17023812

AN - SCOPUS:33749535747

VL - 12

SP - 252

EP - 254

JO - Journal of Clinical Rheumatology

JF - Journal of Clinical Rheumatology

SN - 1076-1608

IS - 5

ER -