MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells

Medicine & Life Sciences

• (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxy-phenyl)-methanone 100%
• 2-dimethylamino-N-(1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl)acetamide 96%
• Tubulin Modulators 65%
• G2 Phase Cell Cycle Checkpoints 54%
• Colorectal Neoplasms 31%
• Apoptosis 24%
• Growth 20%
• HT29 Cells 18%
• Lung Neoplasms 15%
• Glioblastoma 9%
• Cyclin B1 6%
• Breast Neoplasms 6%
• Caspase 9 5%
• G2 Phase 5%
• Tubulin 5%
• Polymerization 5%
• Antineoplastic Agents 4%
• Cell Division 4%
• Caspase 3 4%
• Leukemia 4%
• Cell Cycle 3%
• Cell Survival 3%
• Cell Line 2%
• Neoplasms 1%