Mother-to-child transmission of HIV

An 11-year experience in a single center and HIV prevention effectiveness in Taiwan

Kuan Ying Huang, Yi Ping Li, Chung Ching Shih, Chia Hui Lin, Jessica Kang, Ming Wei Lin, Wen Wei Hsu, Yi Yun Tai, Shin Yu Lin, Hong Nerng Ho

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Background: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) has become an essential global health issue and its elimination is a crucial target. A prenatal “opt-out” HIV screening program was initiated in 2005 in Taiwan. In recent 3 years, approximate screening and MTCT rates were 99% and 2.27% (1/44), respectively. Here, we describe the clinical management of mothers infected with HIV and MTCT rate at National Taiwan University Hospital (NTUH), Taipei, Taiwan, in the years after the program was initiated. Methods: We retrospectively reviewed charts of pregnant women infected with HIV, who were managed at NTUH between January 2005 and December 2016. HIV infection status of 39 infants born to mothers infected with HIV was available. Results: Between 2005 and December 2016, 50 pregnant women infected with HIV, with 57 parities were managed at NTUH, and 57 live infants were born. We excluded 18 parities because of missing data. Maternal antiviral treatment was administered in 37 of 39 infants. Only one infant tested positive for an HIV antibody test at 18 months, but showed definitive HIV exclusion at 20 months after a series of tests without administration of antiviral treatment. MTCT rate was 0%. Conclusion: Successful implementation of available perinatal HIV intervention dramatically reduced vertical transmission rate of HIV. MTCT rate was 0% in NTUH after the program. However, as NTUH is an HIV referral center, additional efforts are needed to achieve the World Health Organization criteria of lowering the vertical transmission rate of HIV to <2% in Taiwan.
原文英語
頁(從 - 到)1211-1217
頁數7
期刊Journal of the Formosan Medical Association
118
發行號8
DOIs
出版狀態已發佈 - 八月 1 2019

指紋

Taiwan
Mothers
HIV
Parity
Antiviral Agents
Pregnant Women
Virus Diseases
Referral and Consultation

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Mother-to-child transmission of HIV : An 11-year experience in a single center and HIV prevention effectiveness in Taiwan. / Huang, Kuan Ying; Li, Yi Ping; Shih, Chung Ching; Lin, Chia Hui; Kang, Jessica; Lin, Ming Wei; Hsu, Wen Wei; Tai, Yi Yun; Lin, Shin Yu; Ho, Hong Nerng.

於: Journal of the Formosan Medical Association, 卷 118, 編號 8, 01.08.2019, p. 1211-1217.

研究成果: 雜誌貢獻文章

Huang, Kuan Ying ; Li, Yi Ping ; Shih, Chung Ching ; Lin, Chia Hui ; Kang, Jessica ; Lin, Ming Wei ; Hsu, Wen Wei ; Tai, Yi Yun ; Lin, Shin Yu ; Ho, Hong Nerng. / Mother-to-child transmission of HIV : An 11-year experience in a single center and HIV prevention effectiveness in Taiwan. 於: Journal of the Formosan Medical Association. 2019 ; 卷 118, 編號 8. 頁 1211-1217.
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title = "Mother-to-child transmission of HIV: An 11-year experience in a single center and HIV prevention effectiveness in Taiwan",
abstract = "Background: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) has become an essential global health issue and its elimination is a crucial target. A prenatal “opt-out” HIV screening program was initiated in 2005 in Taiwan. In recent 3 years, approximate screening and MTCT rates were 99{\%} and 2.27{\%} (1/44), respectively. Here, we describe the clinical management of mothers infected with HIV and MTCT rate at National Taiwan University Hospital (NTUH), Taipei, Taiwan, in the years after the program was initiated. Methods: We retrospectively reviewed charts of pregnant women infected with HIV, who were managed at NTUH between January 2005 and December 2016. HIV infection status of 39 infants born to mothers infected with HIV was available. Results: Between 2005 and December 2016, 50 pregnant women infected with HIV, with 57 parities were managed at NTUH, and 57 live infants were born. We excluded 18 parities because of missing data. Maternal antiviral treatment was administered in 37 of 39 infants. Only one infant tested positive for an HIV antibody test at 18 months, but showed definitive HIV exclusion at 20 months after a series of tests without administration of antiviral treatment. MTCT rate was 0{\%}. Conclusion: Successful implementation of available perinatal HIV intervention dramatically reduced vertical transmission rate of HIV. MTCT rate was 0{\%} in NTUH after the program. However, as NTUH is an HIV referral center, additional efforts are needed to achieve the World Health Organization criteria of lowering the vertical transmission rate of HIV to <2{\%} in Taiwan.",
keywords = "Antiretroviral therapy, Human immunodeficiency virus, Mother-to-child transmission, Opt-out screening, Vertical transmission",
author = "Huang, {Kuan Ying} and Li, {Yi Ping} and Shih, {Chung Ching} and Lin, {Chia Hui} and Jessica Kang and Lin, {Ming Wei} and Hsu, {Wen Wei} and Tai, {Yi Yun} and Lin, {Shin Yu} and Ho, {Hong Nerng}",
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T1 - Mother-to-child transmission of HIV

T2 - An 11-year experience in a single center and HIV prevention effectiveness in Taiwan

AU - Huang, Kuan Ying

AU - Li, Yi Ping

AU - Shih, Chung Ching

AU - Lin, Chia Hui

AU - Kang, Jessica

AU - Lin, Ming Wei

AU - Hsu, Wen Wei

AU - Tai, Yi Yun

AU - Lin, Shin Yu

AU - Ho, Hong Nerng

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) has become an essential global health issue and its elimination is a crucial target. A prenatal “opt-out” HIV screening program was initiated in 2005 in Taiwan. In recent 3 years, approximate screening and MTCT rates were 99% and 2.27% (1/44), respectively. Here, we describe the clinical management of mothers infected with HIV and MTCT rate at National Taiwan University Hospital (NTUH), Taipei, Taiwan, in the years after the program was initiated. Methods: We retrospectively reviewed charts of pregnant women infected with HIV, who were managed at NTUH between January 2005 and December 2016. HIV infection status of 39 infants born to mothers infected with HIV was available. Results: Between 2005 and December 2016, 50 pregnant women infected with HIV, with 57 parities were managed at NTUH, and 57 live infants were born. We excluded 18 parities because of missing data. Maternal antiviral treatment was administered in 37 of 39 infants. Only one infant tested positive for an HIV antibody test at 18 months, but showed definitive HIV exclusion at 20 months after a series of tests without administration of antiviral treatment. MTCT rate was 0%. Conclusion: Successful implementation of available perinatal HIV intervention dramatically reduced vertical transmission rate of HIV. MTCT rate was 0% in NTUH after the program. However, as NTUH is an HIV referral center, additional efforts are needed to achieve the World Health Organization criteria of lowering the vertical transmission rate of HIV to <2% in Taiwan.

AB - Background: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) has become an essential global health issue and its elimination is a crucial target. A prenatal “opt-out” HIV screening program was initiated in 2005 in Taiwan. In recent 3 years, approximate screening and MTCT rates were 99% and 2.27% (1/44), respectively. Here, we describe the clinical management of mothers infected with HIV and MTCT rate at National Taiwan University Hospital (NTUH), Taipei, Taiwan, in the years after the program was initiated. Methods: We retrospectively reviewed charts of pregnant women infected with HIV, who were managed at NTUH between January 2005 and December 2016. HIV infection status of 39 infants born to mothers infected with HIV was available. Results: Between 2005 and December 2016, 50 pregnant women infected with HIV, with 57 parities were managed at NTUH, and 57 live infants were born. We excluded 18 parities because of missing data. Maternal antiviral treatment was administered in 37 of 39 infants. Only one infant tested positive for an HIV antibody test at 18 months, but showed definitive HIV exclusion at 20 months after a series of tests without administration of antiviral treatment. MTCT rate was 0%. Conclusion: Successful implementation of available perinatal HIV intervention dramatically reduced vertical transmission rate of HIV. MTCT rate was 0% in NTUH after the program. However, as NTUH is an HIV referral center, additional efforts are needed to achieve the World Health Organization criteria of lowering the vertical transmission rate of HIV to <2% in Taiwan.

KW - Antiretroviral therapy

KW - Human immunodeficiency virus

KW - Mother-to-child transmission

KW - Opt-out screening

KW - Vertical transmission

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