Morphometric study of glycine-immunoreactive neurons and terminals in the rat cuneate nucleus

J. H. Lue, W. F. Shieh, S. H. Chen, J. Y. Shieh, C. Y. Wen

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12 引文 斯高帕斯(Scopus)

摘要

The distribution of glycine-immunoreactive (glycine-IR) neurons and their associated axon terminals in the rat cuneate nucleus was studied using antiglycine postembedding immunoperoxidase labelling and immunogold staining, respectively. The immunoperoxidase-labelled glycine-IR neurons were widely distributed in the entire rostrocaudal extent of the nucleus. They made up 30.8% (9671/31368) of the neurons surveyed. Quantitative evaluation showed that the percentage of glycine-IR neurons in the caudal level was significantly higher than that in the middle and rostral levels. The glycine-IR neurons were small cells (mean area = 198 ± 1.9 μm 2, n = 2862) with ovoid or spindle-shaped somata. Statistical analysis showed that the size of the glycine-IR neurons in the rostral level was significantly smaller than that in the middle and caudal levels. Immunogold labelled glycine-IR terminals which contained predominantly pleomorphic synaptic vesicles were mostly small (mean area = 1.24 ± 0.03 μm 2, n = 286) and they constituted 24.7% (286/1158) of the total terminals surveyed. They formed axodendritic, axosomatic and axoaxonic synapses with unlabelled elements. It is suggested from this study that glycine is one of the major neurotransmitters involved in the depression of synaptic transmission in the cuneate nucleus.

原文英語
頁(從 - 到)375-385
頁數11
期刊Journal of Anatomy
191
發行號3
DOIs
出版狀態已發佈 - 十月 1997
對外發佈

ASJC Scopus subject areas

  • 農業與生物科學(雜項)
  • 解剖學

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