More than 9-times increased risk for pancreatic cancer among patients with acute pancreatitis in chinese population

Shiu Dong Chung, Kuan Yang Chen, Sudha Xirasagar, Ming Chieh Tsai, Herng Ching Lin

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

Objective: This study aimed to assess the risk of pancreatic cancer after acute pancreatitis using a nationwide population-based data set in Taiwan. Methods: We conducted a retrospective cohort study of 747 patients hospitalized between 2000 and 2003 with a principal diagnosis of acute pancreatitis (the study cohort) and 5976 comparison patients. Stratified Cox proportional hazard regression adjusted for monthly income, urbanization, and geographic location of residence was used to calculate the 5-year hazard ratio (HR) of pancreatic cancer for the study versus comparison cohort. Results: Of the total sample, 21 patients (0.31%) developed pancreatic cancer in the 5 years after index hospitalization: 11 (1.47%) of the study group patients and 10 (0.17%) of the comparison group patients. After adjusting for confounders, acute pancreatitis patients were 9 times as likely as the comparison group to develop pancreatic cancer in the following 5 years (HR = 9.10; 95% confidence interval, 3.81-21.76). Among patients with acute pancreatitis, the adjusted HR of pancreatic cancer was 40.03 and 3.72 times greater, respectively, for those with chronic pancreatitis and for those without than comparison patients. Conclusions: Patients with acute pancreatitis have more than 9 times the risk of comparison patients to develop pancreatic cancer in the subsequent 5 years among the Hun Chinese ethnic population in Taiwan.
原文英語
頁(從 - 到)142-146
頁數5
期刊Pancreas
41
發行號1
DOIs
出版狀態已發佈 - 1月 2012

ASJC Scopus subject areas

  • 肝病
  • 內科學
  • 內分泌
  • 內分泌學、糖尿病和代謝

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