Monohydroxamates of Aspartic Acid and Glutamic Acid Exhibit Antioxidant and Angiotensin Converting Enzyme Inhibitory Activities

Der Zen Liu, Yin Shiou Lin, Wen Chi Hou

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)

摘要

Two monohydroxamates of L-aspartic acid β-hydroxamate (AAH) and L-glutamic acid γ-hydroxamate (GAH) were used for testing antioxidant and angiotensin converting enzyme (ACE) inhibitory activities in comparison with those of asparagine and glutamine, respectively. The half-inhibition concentrations, IC50, of scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were 36 and 48 μM and against superoxide radicals were 18.99 and 6.33 mM, respectively, for AAH and GAH. However, no activities of asparagine and glutamine were found. AAH and GAH also exhibited activities against peroxynitrite-mediated dihydrorhodamine 123 oxidations and hydroxyl radical-mediated DNA damage. For ACE inhibitory activities, the IC50 values were 4.92 and 6.56 mM, respectively, for AAH and GAH. The ACE hydrolyzed products on the TLC chromatogram also confirmed the inhibitory activities of the two amino acid hydroxamates on ACE. When 1.23 mM AAH was added, AAH showed competitive inhibitions against ACE, and the apparent inhibition constant (Ki) was 2.20 mM.

原文英語
頁(從 - 到)2386-2390
頁數5
期刊Journal of Agricultural and Food Chemistry
52
發行號8
DOIs
出版狀態已發佈 - 四月 21 2004

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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