Monascin accelerates anoikis in circulating tumor cells and prevents breast cancer metastasis

Chen Kung‑Yen, Lin Jui‑An, Yao Han‑Yun, Hsu An‑Chih, Tai Yu‑Ting, Ho Bing‑Ying

研究成果: 雜誌貢獻文章同行評審

摘要

Anoikis resistance has been observed in various types of cancers in which anchorage‑independent growth is a crucial step for cancer metastasis. Therefore, agents interfering with this specific cancer cell behavior may be inte‑ grated into novel antimetastatic strategies. Monascin (MS), a secondary metabolite found in Monascus species, is a known potent chemopreventive compound used for treating metabolic complications; however, the effect of MS on anoikis resistance has not been investigated. In this study, 4T1 breast cells were treated with MS under either suspension or adhesion condi‑ tions. The higher cytotoxicity of MS was more potent against suspended cells than against adherent cells. This selective cytotoxicity was due to the induction of anoikis, which was evidenced by changes in cell aggregation, caspase activity, and Annexin V/propidium iodide binding as well as the results of systemic metastasis in an animal model. Furthermore, MS inhibited E‑cadherin and β‑catenin expression in the cells; the treated cells formed spherical aggregates, which suggested that anchorage‑independent growth was prevented by MS. These results provide new insights into the mechanisms under‑ lying the growth‑preventing effect of MS on cancer cells and indicate the potential ability of MS to suppress metastasis.

原文英語
期刊Oncology Letters
20
發行號5
DOIs
出版狀態已發佈 - 八月 2020

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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