Molecular structure of r(GCG)d(TATACGC): A DNA-RNA hybrid helix joined to double helical DNA

Andrew H.J. Wang, Satoshi Fujii, Jacques H. Van Boom, Gijs A. Van Der Marel, Stan A.A. Van Boeckel, Alexander Rich

研究成果: 雜誌貢獻文章同行評審

196 引文 斯高帕斯(Scopus)

摘要

The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA-RNA hybrid segments surrounding a central region of double helical DNA its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2′ hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.

原文英語
頁(從 - 到)601-604
頁數4
期刊Nature
299
發行號5884
DOIs
出版狀態已發佈 - 1982
對外發佈

ASJC Scopus subject areas

  • 多學科

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