Molecular structure of (m5 dC-dG)3: The role of the methyl group on 5-methyl cytosine in stabilizing Z-DNA

Satoshi Fujii, Andrew H.J. Wang, Gijs van der Marel, Jacques H. van Boom, Alexander Rich

研究成果: 雜誌貢獻文章同行評審

153 引文 斯高帕斯(Scopus)

摘要

The hexamer (m5dC-dG)3 has been synthesized and its three-dimensional structure determined by a single crystal X-ray diffraction analysis. The structure has been refined to a final R valne of 15.6% at 1.3 Å resolution. The molecule forms a left-handed Z-DNA helix which is similar to the unmethylated Z-DNA structure. The presence of the methyl group has resulted in slight changes in the twist angle between snccessive base pairs and modification of some of the interatomic contacts. Methylation of cytosine in the C5 position is associated with a relative destabilization of the B-DNA structure and a stabilization through hydrophobic bonding of the Z-DNA structure.

原文英語
頁(從 - 到)7879-7892
頁數14
期刊Nucleic Acids Research
10
發行號23
DOIs
出版狀態已發佈 - 12月 11 1982
對外發佈

ASJC Scopus subject areas

  • 遺傳學

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