Molecular modulation of allergic responses

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9 引文 斯高帕斯(Scopus)

摘要

The pathophysiology of allergic diseases involves an intricate network of molecular and cellular interactions. Elevated levels of serum IgE- and T H2 cytokine-associated eosinophilic inflammation characterize allergic diseases and provide potential targets for immunomodulation. Recent evidence that antigen-induced allergic responses can be modulated in rodents by mucosal transfer of T H1-cytokine genes or by immunization with plasmid DNAs encoding the sensitizing antigens suggests promising new prophylactic or therapeutic approaches. Innovative research in mapping the regulatory pathways that typify the atopy network will provide a deeper understanding of the molecular mechanisms underlying these diseases and facilitate the design of more specific and efficacious modulation strategies.

原文英語
頁(從 - 到)887-892
頁數6
期刊Journal of Allergy and Clinical Immunology
102
發行號6 II
出版狀態已發佈 - 12月 1 1998
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學

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