Molecular genetic characterization of neuroendocrine lung cancer cell lines

S. L. Lai, H. Brauch, T. Knutsen, B. E. Johnson, M. M. Nau, T. Mitsudomi, C. M. Tsai, J. Whang-Peng, B. Zbar, F. J. Kaye, A. F. Gazdar

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39 引文 斯高帕斯(Scopus)

摘要

Small cell lung cancers express neuroendocrine (NE) cell features, while most non-SCLC tumors lack theses features. We studied the cytogenetic and genetic alterations in cell lines derived from three unusual subtypes of lung cancer: including carcinoids, non-small cell lung cancers expressing NE properties (NSCLC-NE) and extrapulmonary small cell cancers (ExPuSC) and compared them with those of SCLC and NSCLC lines. Our studies included: cytogenetic studies, restriction fragment length polymorphism (RFLP) analyses with 8 probes spanning commonly deleted loci on chromosomes 3p, 13p and 17p, retinoblastoma gene product (RB) expression, and mutations in the ras and p53 genes. We also summarize previously published data on in vitro chemosensitivity patterns and MDRl gene expression. Our studies demonstrate that all three of the NE cell subtypes have their own distinctive genotypes and phenotypes, each having some similarities and dissimilarities with SCLC and NSCLC.
原文英語
頁(從 - 到)225-231
頁數7
期刊Anticancer Research
15
發行號2
出版狀態已發佈 - 一月 1 1995
對外發佈

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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