Molecular epidemiology of HIV-1 subtype B, CRF01-AE, and CRF07-BC infection among injection drug users in Taiwan

Yen Ju Chen, Yu Huei Huang, Shao Yuan Chuang, Diana Yu Ting Kao, Yu Ching Lan, Jyh Yuan Yang, Yi Ming Arthur Chen

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

OBJECTIVE: An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07-BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005. METHODS: Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07-BC infection. RESULTS: A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07-BC, subtype B, and CRF01-AE, respectively. Besides CRF07-BC, a new outbreak of CRF01-AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07-BC infection. CONCLUSIONS: Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately.
原文英語
頁(從 - 到)425-439
頁數15
期刊Journal of Acquired Immune Deficiency Syndromes
53
發行號4
DOIs
出版狀態已發佈 - 4月 1 2010
對外發佈

ASJC Scopus subject areas

  • 傳染性疾病
  • 藥學(醫學)

指紋

深入研究「Molecular epidemiology of HIV-1 subtype B, CRF01-AE, and CRF07-BC infection among injection drug users in Taiwan」主題。共同形成了獨特的指紋。

引用此