TY - JOUR
T1 - Molecular epidemiology and trends of HIV-1 subtypes in Taiwan
AU - Chen, Yi Ming A.
AU - Lee, Cheng Ming
AU - Lin, Ruei Yi
AU - Chang, Hong Jen
PY - 1998/12/1
Y1 - 1998/12/1
N2 - To understand the trends of distribution and risk factors associated with different HIV-I subtypes in different populations in Taiwan, blood samples and questionnaires were collected from 267 male and 21 female HIV-1- infected people in a multicenter survey from 1993 to 1996. This group represented about one quarter of the total registered HIV-1 cases in Taiwan. The HIV-1 subtypes were determined using V3-based peptide-enzyme immunoassays complemented by heteroduplex mobility assay and phylogenetic tree analysis. The results showed that in Taiwan, men were primarily infected with HIV-1B (68.2%) and HIV-1E (27.3%), whereas women were mainly infected with non-B subtypes (4.8% A, 4.8% C, 71.4% E, and 9.5% G). In addition, 71.4% of men with HIV-1B were homosexual or bisexual, whereas 56.2% of men with HIV-1E were heterosexual (p < .001). Although HIV-1E subtype came to Taiwan later than HIV-1B, it has become a major subtype in the heterosexual population.
AB - To understand the trends of distribution and risk factors associated with different HIV-I subtypes in different populations in Taiwan, blood samples and questionnaires were collected from 267 male and 21 female HIV-1- infected people in a multicenter survey from 1993 to 1996. This group represented about one quarter of the total registered HIV-1 cases in Taiwan. The HIV-1 subtypes were determined using V3-based peptide-enzyme immunoassays complemented by heteroduplex mobility assay and phylogenetic tree analysis. The results showed that in Taiwan, men were primarily infected with HIV-1B (68.2%) and HIV-1E (27.3%), whereas women were mainly infected with non-B subtypes (4.8% A, 4.8% C, 71.4% E, and 9.5% G). In addition, 71.4% of men with HIV-1B were homosexual or bisexual, whereas 56.2% of men with HIV-1E were heterosexual (p < .001). Although HIV-1E subtype came to Taiwan later than HIV-1B, it has become a major subtype in the heterosexual population.
KW - Heteroduplex mobility assay
KW - HIV-1 genetic sequences
KW - HIV-1 subtypes
KW - Molecular epidemiology
KW - Taiwan
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U2 - 10.1097/00042560-199812010-00011
DO - 10.1097/00042560-199812010-00011
M3 - Article
C2 - 9833749
AN - SCOPUS:0032400935
VL - 19
SP - 393
EP - 402
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
SN - 1525-4135
IS - 4
ER -