Modulation of pulmonary allergic responses by mucosal cytokine-gene transfer

Shau Ku Huang, Xiu Min Li

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Recent clinical and experimental animal studies have provided evidence for a pivotal role of T lymphocytes and Th2 cytokines in the development of allergic inflammatory responses and airway hyperreactivity. These studies suggest also that the Th2 cytokine-associated inflammatory responses are potential targets of developing novel and effective therapies. Using a novel gene-transfer approach, we investigated the role of a Th2-inhibitory cytokine, IFN-?, in the regulation of antigen (Ag)-induced lung inflammatory response and airway hyperreactivity by transfer of the IFN-? gene into mouse lung mucosal cells. Our results showed that mice receiving the IFN-? gene demonstrate a lower degree of Ag- and Th2 cell-induced airway hyperresponsiveness and a reduced eosinophilia in the lung. These results provided evidence that the instillation of the IFN-y gene into the lung is effective in modulating the allergic inflammation and bronchial hyperreactivity in an experimental animal model.

原文英語
頁(從 - 到)11-15
頁數5
期刊Allergology International
46
發行號1
DOIs
出版狀態已發佈 - 1月 1 1997
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏

指紋

深入研究「Modulation of pulmonary allergic responses by mucosal cytokine-gene transfer」主題。共同形成了獨特的指紋。

引用此