Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in rat liver

Jaw Jou Kang, Yi Chien Chen, Wei Chung Kuo, Terri Chen, Yu Wen Cheng, Min Liang Kuo, Tzuu Huei Ueng

研究成果: 雜誌貢獻文章同行評審

20 引文 斯高帕斯(Scopus)

摘要

The present study has determined the effects of Scutellariae Radix(Huangqin) and Gentianae scabrae Radix (Longdan) on liver microsomal cytochrome P450 (P450)-dependent mono-oxygenases using rats pretreated with crude extracts of medicinal herbs. Scutellariae Radix resulted in a 53% decrease of pentoxyresorufin O-dealkylase activity in liver microsomes. In contrast, Gentianae scabrae Radix caused a 50% increase of benzo(a)pyrene hydroxylase activity. Immunoblotting analysis of liver microsomes revealed that Scutellariae Radix induced and suppressed the levels of P450 1A and 2B proteins, respectively. Scutellariae and Gentianae scabrae Radixes had no effects on microsomal aniline hydroxylase activity and P450 2E1 protein.
原文英語
頁(從 - 到)19-29
頁數11
期刊American Journal of Chinese Medicine
24
發行號1
出版狀態已發佈 - 1996
對外發佈

ASJC Scopus subject areas

  • 補充和替代醫學

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