Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex

Tzu Yu Hsu, Lin Yuan Tseng, Jia Xin Yu, Wen Jui Kuo, Daisy L. Hung, Ovid J L Tzeng, Vincent Walsh, Neil G. Muggleton, Chi Hung Juan

研究成果: 雜誌貢獻文章同行評審

141 引文 斯高帕斯(Scopus)

摘要

The executive control of voluntary action involves not only choosing from a range of possible actions but also the inhibition of responses as circumstances demand. Recent studies have demonstrated that many clinical populations, such as people with attention-deficit hyperactivity disorder, exhibit difficulties in inhibitory control. One prefrontal area that has been particularly associated with inhibitory control is the pre-supplementary motor area (Pre-SMA). Here we applied non-invasive transcranial direct current stimulation (tDCS) over Pre-SMA to test its role in this behavior. tDCS allows for current to be applied in two directions to selectively excite or suppress the neural activity of Pre-SMA. Our results showed that anodal tDCS improved efficiency of inhibitory control. Conversely, cathodal tDCS showed a tendency towards impaired inhibitory control. To our knowledge, this is the first demonstration of non-invasive intervention tDCS altering subjects' inhibitory control. These results further our understanding of the neural bases of inhibitory control and suggest a possible therapeutic intervention method for clinical populations.
原文英語
頁(從 - 到)2249-2257
頁數9
期刊NeuroImage
56
發行號4
DOIs
出版狀態已發佈 - 六月 15 2011
對外發佈Yes

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

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