Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni

Tina Tu Wen Chen, Lawrence Shih Hsin Wu, Paul Wei Che Hsu, Cheng Yoong Pang, Kin Mu Lee, Po Ching Cheng, Shih Yi Peng

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Mitochondrial dynamics is crucial for regulation of cell homeostasis. Schistosoma mansoni is one of the most common parasites known to cause liver disease. Mice infected by S. mansoni show acute symptoms of schistosomiasis after 8 weeks. Hence, in this study, we attempted to assess the direct effects of S. mansoni infection on mice liver, and to explore the expression of mitochondrial morphology, dynamics, and function. Our recent findings show that S. mansoni infection changes mitochondrial morphology and affects mitochondrial functions, which attenuates mitochondrial membrane potential and ATP generation. S. mansoni-infected mice increases mitochondrial numbers by upregulating of genes involved in mitochondrial biogenesis, including peroxisome proliferator-activated receptor c co-activator 1α (PGC1α) and mitochondrial transcription factor A (Tfam). This may promote mitochondria generation for accelerating the recovery of mitochondrial functions. Moreover, S. mansoni would disrupt mitochondrial dynamics including induced mitochondrial fission and promoted mitochondrial fragmentation in mice liver. More importantly, S. mansoni further stimulated upregulation both extrinsic and intrinsic apoptosis pathway in infected mice liver. The intrinsic pathway was triggered by cytochrome c release. Additionally, NFκB (nuclear factor-kappa B, p65) could play a protective role to inhibit apoptosis through reducing active caspase-3 expression. Therefore, our results confirmed the liver damage mechanism of experimental schistosomiasis in mice model.

原文英語
頁(從 - 到)13-23
頁數11
期刊Acta Tropica
148
DOIs
出版狀態已發佈 - 八月 1 2015

指紋

Mitochondrial Dynamics
Schistosoma mansoni
liver
Liver
mice
Schistosomiasis mansoni
Schistosomiasis
schistosomiasis
Apoptosis
apoptosis
Peroxisome Proliferator-Activated Receptors
NF-kappa B
Mitochondrial Membrane Potential
Recovery of Function
Organelle Biogenesis
Cytochromes c
cytochrome c
Caspase 3
liver diseases
caspase-3

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

引用此文

Chen, T. T. W., Wu, L. S. H., Hsu, P. W. C., Pang, C. Y., Lee, K. M., Cheng, P. C., & Peng, S. Y. (2015). Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni. Acta Tropica, 148, 13-23. https://doi.org/10.1016/j.actatropica.2015.04.004

Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni. / Chen, Tina Tu Wen; Wu, Lawrence Shih Hsin; Hsu, Paul Wei Che; Pang, Cheng Yoong; Lee, Kin Mu; Cheng, Po Ching; Peng, Shih Yi.

於: Acta Tropica, 卷 148, 01.08.2015, p. 13-23.

研究成果: 雜誌貢獻文章

Chen, Tina Tu Wen ; Wu, Lawrence Shih Hsin ; Hsu, Paul Wei Che ; Pang, Cheng Yoong ; Lee, Kin Mu ; Cheng, Po Ching ; Peng, Shih Yi. / Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni. 於: Acta Tropica. 2015 ; 卷 148. 頁 13-23.
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