Mismatch negativity to the patient's own name in chronic disorders of consciousness

Pengmin Qin, Haibo Di, Xiaodan Yan, Senming Yu, Dan Yu, Steven Laureys, Xuchu Weng

研究成果: 雜誌貢獻文章

78 引文 斯高帕斯(Scopus)

摘要

Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4), vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. © 2008 Elsevier Ireland Ltd. All rights reserved.
原文英語
頁(從 - 到)24-28
頁數5
期刊Neuroscience Letters
448
發行號1
DOIs
出版狀態已發佈 - 2008
對外發佈Yes

Keywords

  • Disorders of consciousness
  • Vegetative state
  • Own name
  • Mismatch negativity
  • Minimally conscious state

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