MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol

Y. H. Yu, H. A. Chen, P. S. Chen, Y. J. Cheng, W. H. Hsu, Y. W. Chang, Y. H. Chen, Y. Jan, M. Hsiao, T. Y. Chang, Y. H. Liu, Y. M. Jeng, C. H. Wu, M. T. Huang, Yen-Hao Su, M. C. Hung, M. H. Chien, C. Y. Chen, M. L. Kuo, J. L. Su

研究成果: 雜誌貢獻文章

88 引文 斯高帕斯(Scopus)

摘要

Resveratrol, a phytochemical found in various plants and Chinese herbs, is associated with multiple tumor-suppressing activities, has been tested in clinical trials. However, the molecular mechanisms involved in resveratrol-mediated tumor suppressing activities are not yet completely defined. Here, we showed that treatment with resveratrol inhibited cell mobility through induction of the mesenchymal-epithelial transition (MET) in lung cancer cells. We also found that downregulation of FOXC2 (forkhead box C2) is critical for resveratrol-mediated suppression of tumor metastasis in an in vitro and in vivo models. We also identified a signal cascade, namely, resveratrol - |miRNA-520h - |PP2A/C - |Akt → NF-κB → FOXC2, in which resveratrol inhibited the expression of FOXC2 through regulation of miRNA-520h-mediated signal cascade. This study identified a new miRNA-520h-related signal cascade involved in resveratrol-mediated tumor suppression activity and provide the clinical significances of miR-520h, PP2A/C and FOXC2 in lung cancer patients. Our results indicated a functional link between resveratrol-mediated miRNA-520h regulation and tumor suppressing ability, and provide a new insight into the role of resveratrol-induced molecular and epigenetic regulations in tumor suppression.

原文英語
頁(從 - 到)431-443
頁數13
期刊Oncogene
32
發行號4
DOIs
出版狀態已發佈 - 一月 24 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

指紋 深入研究「MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol」主題。共同形成了獨特的指紋。

  • 引用此

    Yu, Y. H., Chen, H. A., Chen, P. S., Cheng, Y. J., Hsu, W. H., Chang, Y. W., Chen, Y. H., Jan, Y., Hsiao, M., Chang, T. Y., Liu, Y. H., Jeng, Y. M., Wu, C. H., Huang, M. T., Su, Y-H., Hung, M. C., Chien, M. H., Chen, C. Y., Kuo, M. L., & Su, J. L. (2013). MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol. Oncogene, 32(4), 431-443. https://doi.org/10.1038/onc.2012.74