MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

X. Fu, Z. Meng, W. Liang, Y. Tian, X. Wang, W. Han, G. Lou, X. Wang, F. Lou, Y. Yen, H. Yu, R. Jove, W. Huang

研究成果: 雜誌貢獻文章

70 引文 (Scopus)

摘要

Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway represents a novel strategy for cancer therapy. Here, we report that miR-26a enhances miRNA biogenesis, which acts as a common mechanism partially accounting for miR-26a function in diverse cancers including melanoma, prostate and liver cancer. miR-26a was broadly reduced in multiple cancers, and overexpression of miR-26a significantly suppressed tumor growth and metastasis both in vitro and in vivo, including melanoma, prostate and liver cancers. Notably, miR-26a overexpression was accompanied by global upregulation of miRNAs, especially let-7, and let-7 expression was concordant with miR-26a expression in cancer cell lines, xenograft tumors and normal human tissues, underscoring their biological relevance. We showed that miR-26a directly targeted Lin28B and Zcchc11 - two critical repressors of let-7 maturation. Furthermore, we have demonstrated that Zcchc11 promoted tumor growth and metastasis, and it was prominently overexpressed in human cancers. Our findings thus provide a novel mechanism by which a miRNA acts as a modulator of miRNA biogenesis. These results also define a role of the miR-26a and Zcchc11 in tumorigenesis and metastasis and have implications to develop new strategies for cancer therapy.
原文英語
頁(從 - 到)4296-4306
頁數11
期刊Oncogene
33
發行號34
DOIs
出版狀態已發佈 - 八月 21 2014
對外發佈Yes

指紋

MicroRNAs
Neoplasm Metastasis
Growth
Neoplasms
Liver Neoplasms
Melanoma
Prostatic Neoplasms
Tumor Cell Line
Heterografts
Carcinogenesis
Up-Regulation
Therapeutics

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

引用此文

Fu, X., Meng, Z., Liang, W., Tian, Y., Wang, X., Han, W., ... Huang, W. (2014). MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. Oncogene, 33(34), 4296-4306. https://doi.org/10.1038/onc.2013.385

MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. / Fu, X.; Meng, Z.; Liang, W.; Tian, Y.; Wang, X.; Han, W.; Lou, G.; Wang, X.; Lou, F.; Yen, Y.; Yu, H.; Jove, R.; Huang, W.

於: Oncogene, 卷 33, 編號 34, 21.08.2014, p. 4296-4306.

研究成果: 雜誌貢獻文章

Fu, X, Meng, Z, Liang, W, Tian, Y, Wang, X, Han, W, Lou, G, Wang, X, Lou, F, Yen, Y, Yu, H, Jove, R & Huang, W 2014, 'MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis', Oncogene, 卷 33, 編號 34, 頁 4296-4306. https://doi.org/10.1038/onc.2013.385
Fu, X. ; Meng, Z. ; Liang, W. ; Tian, Y. ; Wang, X. ; Han, W. ; Lou, G. ; Wang, X. ; Lou, F. ; Yen, Y. ; Yu, H. ; Jove, R. ; Huang, W. / MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. 於: Oncogene. 2014 ; 卷 33, 編號 34. 頁 4296-4306.
@article{cf82fd1b92874190a776d81b2c2d42e0,
title = "MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis",
abstract = "Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway represents a novel strategy for cancer therapy. Here, we report that miR-26a enhances miRNA biogenesis, which acts as a common mechanism partially accounting for miR-26a function in diverse cancers including melanoma, prostate and liver cancer. miR-26a was broadly reduced in multiple cancers, and overexpression of miR-26a significantly suppressed tumor growth and metastasis both in vitro and in vivo, including melanoma, prostate and liver cancers. Notably, miR-26a overexpression was accompanied by global upregulation of miRNAs, especially let-7, and let-7 expression was concordant with miR-26a expression in cancer cell lines, xenograft tumors and normal human tissues, underscoring their biological relevance. We showed that miR-26a directly targeted Lin28B and Zcchc11 - two critical repressors of let-7 maturation. Furthermore, we have demonstrated that Zcchc11 promoted tumor growth and metastasis, and it was prominently overexpressed in human cancers. Our findings thus provide a novel mechanism by which a miRNA acts as a modulator of miRNA biogenesis. These results also define a role of the miR-26a and Zcchc11 in tumorigenesis and metastasis and have implications to develop new strategies for cancer therapy.",
keywords = "let-7, metastasis, miR-26a, miRNA biogenesis, tumorigenesis, Zcchc11",
author = "X. Fu and Z. Meng and W. Liang and Y. Tian and X. Wang and W. Han and G. Lou and X. Wang and F. Lou and Y. Yen and H. Yu and R. Jove and W. Huang",
year = "2014",
month = "8",
day = "21",
doi = "10.1038/onc.2013.385",
language = "English",
volume = "33",
pages = "4296--4306",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "34",

}

TY - JOUR

T1 - MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

AU - Fu, X.

AU - Meng, Z.

AU - Liang, W.

AU - Tian, Y.

AU - Wang, X.

AU - Han, W.

AU - Lou, G.

AU - Wang, X.

AU - Lou, F.

AU - Yen, Y.

AU - Yu, H.

AU - Jove, R.

AU - Huang, W.

PY - 2014/8/21

Y1 - 2014/8/21

N2 - Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway represents a novel strategy for cancer therapy. Here, we report that miR-26a enhances miRNA biogenesis, which acts as a common mechanism partially accounting for miR-26a function in diverse cancers including melanoma, prostate and liver cancer. miR-26a was broadly reduced in multiple cancers, and overexpression of miR-26a significantly suppressed tumor growth and metastasis both in vitro and in vivo, including melanoma, prostate and liver cancers. Notably, miR-26a overexpression was accompanied by global upregulation of miRNAs, especially let-7, and let-7 expression was concordant with miR-26a expression in cancer cell lines, xenograft tumors and normal human tissues, underscoring their biological relevance. We showed that miR-26a directly targeted Lin28B and Zcchc11 - two critical repressors of let-7 maturation. Furthermore, we have demonstrated that Zcchc11 promoted tumor growth and metastasis, and it was prominently overexpressed in human cancers. Our findings thus provide a novel mechanism by which a miRNA acts as a modulator of miRNA biogenesis. These results also define a role of the miR-26a and Zcchc11 in tumorigenesis and metastasis and have implications to develop new strategies for cancer therapy.

AB - Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway represents a novel strategy for cancer therapy. Here, we report that miR-26a enhances miRNA biogenesis, which acts as a common mechanism partially accounting for miR-26a function in diverse cancers including melanoma, prostate and liver cancer. miR-26a was broadly reduced in multiple cancers, and overexpression of miR-26a significantly suppressed tumor growth and metastasis both in vitro and in vivo, including melanoma, prostate and liver cancers. Notably, miR-26a overexpression was accompanied by global upregulation of miRNAs, especially let-7, and let-7 expression was concordant with miR-26a expression in cancer cell lines, xenograft tumors and normal human tissues, underscoring their biological relevance. We showed that miR-26a directly targeted Lin28B and Zcchc11 - two critical repressors of let-7 maturation. Furthermore, we have demonstrated that Zcchc11 promoted tumor growth and metastasis, and it was prominently overexpressed in human cancers. Our findings thus provide a novel mechanism by which a miRNA acts as a modulator of miRNA biogenesis. These results also define a role of the miR-26a and Zcchc11 in tumorigenesis and metastasis and have implications to develop new strategies for cancer therapy.

KW - let-7

KW - metastasis

KW - miR-26a

KW - miRNA biogenesis

KW - tumorigenesis

KW - Zcchc11

UR - http://www.scopus.com/inward/record.url?scp=84906936211&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906936211&partnerID=8YFLogxK

U2 - 10.1038/onc.2013.385

DO - 10.1038/onc.2013.385

M3 - Article

VL - 33

SP - 4296

EP - 4306

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 34

ER -