miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts

Wei Ting Chang, Jhih Yuan Shih, Yu Wen Lin, Tzu Ling Huang, Zhih Cherng Chen, Chi Long Chen, Jan Show Chu, Ping Yen Liu

研究成果: 雜誌貢獻文章同行評審

摘要

Young and aging hearts undergo different remodeling post pressure overload, but the regulator that determines responses to pressure overload at different ages remains unknown. With an angiotensin II (Ang II)-induced hypertensive model, miR-21 knockout mice (miR-21−/−) were observed regarding the effects of miR-21 on hypertension-induced cardiac remodeling in young (12 week-old) and old (50 week-old) mice. Although the aged heart represented a more significant hypertrophy and was associated with a higher expression of miR-21, Ang II-induced cardiac hypertrophy was attenuated in miR-21−/− mice. Upon results of cardiac-specific arrays in miR-21-overexpressing cardiomyocytes, we found a significant downregulation of S100a8. In both in vitro and in vivo models, miR-21/S100a8/NF-κB/NFAT pathway was observed to be associated with pressure overload-induced hypertrophic remodeling in aged hearts. To further investigate whether circulating miR-21 could be a biomarker reflecting the aged associated cardiac remodeling, we prospectively collected clinical and echocardiographic information of patients at young (
原文英語
頁(從 - 到)5925-5945
頁數21
期刊Aging
14
發行號14
DOIs
出版狀態已發佈 - 2022

ASJC Scopus subject areas

  • 老化
  • 細胞生物學

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