Middle cerebral artery calcification: Association with ischemic stroke

Hung Wen Kao, Michelle Liou, Hsiao Wen Chung, Hua-Shan Liu, Ping-Huei Tsai, Shih Wei Chiang, Ming Chung Chou, Giia Sheun Peng, Guo Shu Huang, Hsian He Hsu, Cheng-Yu Chen

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)


Calcification of the middle cerebral artery (MCA) is uncommon in the healthy elderly. Whether calcification of the MCA is associated with cerebral ischemic stroke remains undetermined. We intended to investigate the association using Agatston calcium scoring of the MCA. This study retrospectively included 354 subjects with ischemic stroke in the MCA territory and 1518 control subjects who underwent computed tomography (CT) of the brain. We recorded major known risk factors for ischemic stroke, including age, gender, hypertension, diabetes mellitus, smoking, hyperlipidemia, and obesity, along with the MCA calcium burden, measured with the Agatston calcium scoring method. Univariate and modified logistic regression analyses were performed to examine the association between the MCA calcification and ischemic stroke. The univariate analyses showed significant associations of ischemic stroke with age, hypertension, diabetes mellitus, smoking, total MCA Agatston score, and the presence of calcification on both or either side of the MCA. Subjects with the presence of MCA calcification on both or either side of the MCA were 8.46 times (95% confidence interval, 4.93-14.53; P<0.001) more likely to have a cerebral infarct than subjects without MCA calcification after adjustment for the major known risk factors, including age, hypertension, diabetes mellitus, and smoking. However, a higher degree of MCA calcification reflected by the Agatston score was not associated with higher risk of MCA ischemic stroke after adjustment for the confounding factors and presence of MCA calcification. These results suggest that MCA calcification is associated with ischemic stroke in the MCA territory. Further prospective studies are required to verify the clinical implications of the MCA calcification.
期刊Medicine (United States)
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • 醫藥 (全部)


深入研究「Middle cerebral artery calcification: Association with ischemic stroke」主題。共同形成了獨特的指紋。