Microstructural white matter tissue characteristics are modulated by homocysteine: A diffusion tensor imaging study

Rong-Long Shiu, Wei Hung Chen, Chyi Huey Bai, Jyu Gang Leu, Chien-Yeh Hsu, Max A. Viergever, Alexander Leemans

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Homocysteine level can lead to adverse effects on the brain white matter through endothelial dysfunction, microstructural inflammation, and neurotoxin effects. Despite previously observed associations between elevated homocysteine and macroscopic structural brain changes, it is still unknown whether microstructural associations of homocysteine on brain tissue properties can be observed in healthy subjects with routine MRI. To this end, we investigated potential relationships between homocysteine levels and microstructural measures computed with diffusion tensor imaging (DTI) in a cohort of 338 healthy participants. Significant positive correlations were observed between homocysteine levels and diffusivity measures in the bilateral temporalWM, the brainstem, and the bilateral cerebellar peduncle. This is the first study demonstrating that DTI is sufficiently sensitive to relate microstructural WM properties to homocysteine levels in healthy subjects.

原文英語
文章編號e0116330
期刊PLoS One
10
發行號2
DOIs
出版狀態已發佈 - 二月 18 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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