Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study

Jung Lung Hsu, Yen Ling Chen, Jyu Gang Leu, Fu Shan Jaw, Cheng Hui Lee, Yuh Feng Tsai, Chien-Yeh Hsu, Chyi Huey Bai, Alexander Leemans

研究成果: 雜誌貢獻文章

104 引文 (Scopus)

摘要

This study investigated whether diffusion tensor imaging (DTI) could identify potential abnormalities in type 2 diabetes mellitus (T2DM) patients without cognitive complaints compared to healthy controls. In addition, the existence of associations between diffusion measures and clinical parameters was examined. Forty T2DM patients and 97 non-diabetic controls completed a clinical and biochemistry examination. Structural MRI scans (DTI, T1, T2, FLAIR) were subsequently acquired with a 1.5 Tesla scanner. In addition to a global DTI analysis, voxel-based analysis was performed on the fractional anisotropy (FA), mean diffusivity (MD), and axial (AD) and transverse (TD) diffusivity maps to investigate regions that exhibit (i) WM differences between patients and controls; and (ii) associations between clinical measurements and these DTI indices. There were no significant differences in age, gender, and WM hyperintensity scores derived by the conventional MRI scans between controls and T2DM patients. For the T2DM patients, however, the MD of the brain parenchyma was significantly increased compared to controls and was positively correlated with disease duration. The voxel based analyses revealed (i) a significantly decreased FA in the bilateral frontal WM compared to controls which was mainly caused by an increased TD and not a decreased AD within these regions; (ii) a significant association between disease duration and microstructural properties in several brain regions including bilateral cerebellum, temporal lobe WM, right caudate, bilateral cingulate gyrus, pons, and parahippocampal gyrus. Our findings indicate that microstructural WM abnormalities and associations with clinical measurements can be detected with DTI in T2DM patients.

原文英語
頁(從 - 到)1098-1105
頁數8
期刊NeuroImage
59
發行號2
DOIs
出版狀態已發佈 - 一月 16 2012

指紋

Diffusion Tensor Imaging
Type 2 Diabetes Mellitus
Anisotropy
Magnetic Resonance Imaging
Parahippocampal Gyrus
Pons
Gyrus Cinguli
Brain
Temporal Lobe
Biochemistry
Cerebellum
White Matter

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

引用此文

Hsu, J. L., Chen, Y. L., Leu, J. G., Jaw, F. S., Lee, C. H., Tsai, Y. F., ... Leemans, A. (2012). Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study. NeuroImage, 59(2), 1098-1105. https://doi.org/10.1016/j.neuroimage.2011.09.041

Microstructural white matter abnormalities in type 2 diabetes mellitus : A diffusion tensor imaging study. / Hsu, Jung Lung; Chen, Yen Ling; Leu, Jyu Gang; Jaw, Fu Shan; Lee, Cheng Hui; Tsai, Yuh Feng; Hsu, Chien-Yeh; Bai, Chyi Huey; Leemans, Alexander.

於: NeuroImage, 卷 59, 編號 2, 16.01.2012, p. 1098-1105.

研究成果: 雜誌貢獻文章

Hsu, JL, Chen, YL, Leu, JG, Jaw, FS, Lee, CH, Tsai, YF, Hsu, C-Y, Bai, CH & Leemans, A 2012, 'Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study', NeuroImage, 卷 59, 編號 2, 頁 1098-1105. https://doi.org/10.1016/j.neuroimage.2011.09.041
Hsu, Jung Lung ; Chen, Yen Ling ; Leu, Jyu Gang ; Jaw, Fu Shan ; Lee, Cheng Hui ; Tsai, Yuh Feng ; Hsu, Chien-Yeh ; Bai, Chyi Huey ; Leemans, Alexander. / Microstructural white matter abnormalities in type 2 diabetes mellitus : A diffusion tensor imaging study. 於: NeuroImage. 2012 ; 卷 59, 編號 2. 頁 1098-1105.
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