MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Chiu Chun Chang, Chun Che Lin, Wan Ling Hsieh, Hsin Wu Lai, Chia Hsun Tsai, Ya Wen Cheng

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.
原文英語
文章編號367157
期刊Disease Markers
2014
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • 生物化學(醫學)
  • 臨床生物化學
  • 分子生物學
  • 遺傳學

指紋

深入研究「MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C」主題。共同形成了獨特的指紋。

引用此