Microcalorimetric investigation of the interaction of polysorbate surfactants with unilamellar phosphatidylcholines liposomes

Li Min Tasi, Der Zen Liu, Wen Yih Chen

研究成果: 雜誌貢獻文章同行評審

39 引文 斯高帕斯(Scopus)

摘要

The physical stability of liposome was discussed by the zeta potential and isothermal titration calorimetry (ITC) measurements. In our system, the liposomes containing egg-PC, α-tocopherol and various quantities of polysorbate susfactants (Tween 20 and Tween 80) were prepared herein by the probe sonication method. The stability of these liposomes were also monitored and discussed by examining the size change with incubation time and the permeability of hydrophilic fluorescence (5(6)-carboxyfluorescein) probe. The experimental results demonstrated that adding Tween surfactants accelerated the change in liposomal size. Although adding 4 wt.% Tween surfactants had no effect on the permeability at 298 K, the permeability was promoted both at 298 and 310 K as the additional Tween surfactants increased to 8 wt.%. The zeta potential of liposome and the interaction potential between the liposomes were obtained by photon correlation spectroscopy (PCS) and by ITC. The experimental results demonstrated that adding the Tween surfactants increased the attractive interaction potential between the liposomes, whereas, the zeta potential of liposomes with the Tween surfactants was not varied from liposomes without surfactants at 298 K. The increase attractive interaction potential can be attributed to the increase in hydrophobic interactions between the (CH2-CH2-O)n groups on the Tween surfactant's headgroup.

原文英語
頁(從 - 到)7-14
頁數8
期刊Colloids and Surfaces A: Physicochemical and Engineering Aspects
213
發行號1
DOIs
出版狀態已發佈 - 二月 4 2003

ASJC Scopus subject areas

  • 膠體和表面化學
  • 物理與理論化學

指紋

深入研究「Microcalorimetric investigation of the interaction of polysorbate surfactants with unilamellar phosphatidylcholines liposomes」主題。共同形成了獨特的指紋。

引用此